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dc.contributor.authorInan, Ayse
dc.contributor.authorSunbul, Ali Burak
dc.contributor.authorIkiz, Mesut
dc.contributor.authorTayhan, Secil Erden
dc.contributor.authorBilgin, Sema
dc.contributor.authorElmastas, Mahfuz
dc.contributor.authorSayin, Koray
dc.contributor.authorCeyhan, Gokhan
dc.contributor.authorKose, Muhammet
dc.contributor.authorIspir, Esin
dc.descriptionWOS: 000438484600010en_US
dc.description.abstractThree novel azo-azomethine ligands have been synthesized in an accomplished one-pot synthesis protocol. The mononuclear Ru(II) complexes of these azo-azomethine dyes were prepared and characterized by the combination of elemental analyses, IR, UV-Visible spectroscopy and H-1-C-13 NMR spectra. Solid state structures of 3, 4 and 7 were determined by single crystal X-ray diffraction studies. The electrochemical and photoluminescence properties of the compounds were studied. The 1931 CIE (x, y) chromaticity coordinates of the ligands and their metal complexes were investigated and the x, y values of the compounds were found to be close to the National Television Standard Committee (NTSC) standard. Quantum chemical calculation of related ligands and complexes are performed at B3LYP/6-31G(d, p) and B3LYP/6-31G(d, p) (LANL2DZ) level in vacuum. In addition, the azo-azomethine ligands and their Ru(II) complexes were evaluated for both their in-vitro antibacterial activity by the disc diffusion method and antioxidant properties using ferric reduction power, DPPH free radical, and ABTS cation radical scavenging activities as in vitro. Radical scavenging activities of compounds 5-7 were found higher than BHT, BHA, and Trolox used as positive controls. Compounds 2-4 antioxidant capacities were lower than the positive controls. Finally, the new azoazomethine dyes and their Ru(II) complexes were investigated for their in vitro antiproliferative activities against non-small cell lung cancer cells (H2126), prostate adenocarcinoma cells (PC3) and breast cancer cells (MCF7) in vitro. Cell proliferation test were performed as dose-dependent assays at 200 mu M. The new azo-azomethine ligands and their Ru(II) complexes have shown anticancer activity on the studied cell lines after 24 h exposure to 200 mu M compounds. However, the activities of the compounds are much lower than 5-Fu. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipUnit of Coordination of Scientific Research Projects, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey [2015/1-16YLS]en_US
dc.description.sponsorshipThis work was financially supported by the Unit of Coordination of Scientific Research Projects, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey (Project no: 2015/1-16YLS).en_US
dc.subjectRu(II) complexesen_US
dc.subjectAnticancer activityen_US
dc.subjectAntioxidant propertiesen_US
dc.titleHalf-sandwich Ruthenium(II) arene complexes bearing the azo-azomethine ligands: Electrochemical, computational, antiproliferative and antioxidant propertiesen_US
dc.contributor.department[Inan, Ayse -- Sunbul, Ali Burak -- Kose, Muhammet -- Ispir, Esin] Kahramanmaras Sutcu Imam Univ, Fac Sci & Arts, Dept Chem, TR-460509 Kahramanmaras, Turkey -- [Ikiz, Mesut] Univ Hlth Sci, Vocat Sch Hlth Serv, Dept Med Serv & Tech, TR-34668 Istanbul, Turkey -- [Tayhan, Secil Erden] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Genet & Bioengn, TR-60240 Tokat, Turkey -- [Bilgin, Sema] Gaziosmanpasa Univ, Fac Sci & Arts, Dept Chem, TR-60240 Tokat, Turkey -- [Elmastas, Mahfuz] Univ Hlth Sci, Fac Pharm, Dept Basic Pharm Sci, TR-34668 Istanbul, Turkey -- [Sayin, Koray] Cumhuriyet Univ, Fac Sci, Dept Chem, TR-58140 Sivas, Turkey -- [Ceyhan, Gokhan] Kahramanmaras Sutcu Imam Univ, Res & Dev Ctr Univ Ind Publ Relat, TR-460509 Kahramanmaras, Turkeyen_US
dc.contributor.authorIDIspir, Esin -- 0000-0001-8681-9858en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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