dc.contributor.author | Abakay, Ugur | |
dc.contributor.author | Soylu, Sinan | |
dc.contributor.author | Goksel, Sabahattin | |
dc.contributor.author | Sarac, Bulent | |
dc.contributor.author | Inan, Zeynep Deniz Sahin | |
dc.contributor.author | Cakmak, Erol | |
dc.contributor.author | Korkmaz, Ozge | |
dc.contributor.author | Kurt, Atilla | |
dc.contributor.author | Genc, Husnu Cagri | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:37:46Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:37:46Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1306-696X | |
dc.identifier.uri | https://dx.doi.org/10.5505/tjtes.2018.22227 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6175 | |
dc.description | WOS: 000446506600004 | en_US |
dc.description | PubMed ID: 30394491 | en_US |
dc.description.abstract | BACKGROUND: Intestinal ischemia-reperfusion (I/R) injury can lead to multiple organ failure and death. The aim of this study was to investigate the effects of pentoxifylline and iloprost administered before reperfusion in intestinal ischemia. METHODS: In total, 25 male Wistar Albino rats weighing 250-300 g were divided into five groups each comprising five subjects: control group (n=5), sham group (n=5, no I/R), I/R group (n=5, 45 min ischemia, and 120 min reperfusion), I/R + pentoxifylline group (n=5, 45 min ischemia following intraperitoneal 50 mg/kg pentoxifylline and 120 min reperfusion), and I/R + iloprast group (n=5, 45 min ischemia followed by intraperitoneal 2 mcg/kg iloprost and 120 min reperfusion). At the end of the experiment, ileum specimens were stained using hematoxylin-eosin and histopathologically evaluated using the Chiu score. Isometric contraction-relaxation responses were recorded using organ baths for contraction-relaxation responses. RESULTS: Pentoxifylline provided a significant improvement in response to histopathological and contraction-relaxation responses. Although iloprost provided recovery in reperfusion injury, it was not statistically significant. CONCLUSION: Our findings demonstrate that pentoxifylline may be promising in preventing small bowel ischemia-reperfusion injury. We concluded that further clinical and experimental studies for iloprost are needed. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TURKISH ASSOC TRAUMA EMERGENCY SURGERY | en_US |
dc.relation.isversionof | 10.5505/tjtes.2018.22227 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acute mesenteric ischemia | en_US |
dc.subject | iloprost | en_US |
dc.subject | ischemia-reperfusion injury | en_US |
dc.subject | pentoxifylline | en_US |
dc.title | Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY | en_US |
dc.contributor.department | [Abakay, Ugur -- Soylu, Sinan -- Kurt, Atilla -- Genc, Husnu Cagri] Cumhuriyet Univ, Dept Gen Surg, Fac Med, Sivas, Turkey -- [Goksel, Sabahattin -- Korkmaz, Ozge] Cumhuriyet Univ, Dept Cardiovasc Surg, Fac Med, Sivas, Turkey -- [Sarac, Bulent] Cumhuriyet Univ, Dept Pharmacol, Fac Med, Sivas, Turkey -- [Inan, Zeynep Deniz Sahin] Cumhuriyet Univ, Dept Histol, Fac Med, Sivas, Turkey -- [Cakmak, Erol] Cumhuriyet Univ, Dept Gastroenterol, Fac Med, Sivas, Turkey | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 404 | en_US |
dc.identifier.startpage | 398 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |