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dc.contributor.authorUner, Aykut G.
dc.contributor.authorUnsal, Cengiz
dc.contributor.authorUnsal, Humeyra
dc.contributor.authorErdogan, Mumin A.
dc.contributor.authorKoc, Ece
dc.contributor.authorEkici, Mehmet
dc.contributor.authorAvci, Hamdi
dc.contributor.authorBalkaya, Muharrem
dc.contributor.authorBelge, Ferda
dc.contributor.authorTarin, Lokman
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:38:21Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:38:21Z
dc.date.issued2018
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.urihttps://dx.doi.org/10.1097/MBC.0000000000000713
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6320
dc.descriptionWOS: 000431511000003en_US
dc.descriptionPubMed ID: 29624513en_US
dc.description.abstractClassical risk factors such as cholesterol and lipoproteins are currently not sufficient to explain all physiopathological processes of obesity-related vascular dysfunction as well as atherosclerosis and arteriosclerosis. Therefore, the discovery of potential markers involved in vascular dysfunction in the obese state is still needed. Disturbances in hemostatic factors may be involved in the developmental processes associated with obesity-related cardiovascular disorders. We hypothesized that alterations of several hemostatic factors in the obese state could correlate with the function and morphology of the aorta and it could play an important role in the development of vascular dysfunction. To test this, we fed mice with a high-fat diet for 18 weeks and investigated the relationships between selected hemostatic factors (in either plasma or in the liver), metabolic hormones and morphology, and ex-vivo function of the aorta. Here, we show that 18-week exposure to a high-fat diet results in a higher plasma fibrinogen and prolonged prothrombin time in diet-induced obese mice compared to the controls. In addition, liver levels or activities of FII, FX, activated protein C, AT-III, and protein S are significantly different in diet-induced obese mice as compared to the controls. Curiously, FII, FVIII, FX, activated protein C, PTT, and protein S are correlated with both the aorta histology (aortic thickness and diameter) and ex-vivo aortic function. Notably, ex-vivo studies revealed that diet-induced obese mice show a marked attenuation in the functions of the aorta. Taken together, aforementioned hemostatic factors may be considered as critical markers for obesity-related vascular dysfunction and they could play important roles in diagnosing of the dysfunction.en_US
dc.description.sponsorshipAdnan Menderes University [VTF-12006, VTF-14027]en_US
dc.description.sponsorshipA.G.U. and M.B. designed research; C.U., A.G.U., H.U., M.A.E., E.K., M.E., H.A., F.B., and L.T. performed research; C.U., A.G.U., M.B., and L.T. analyzed data; C.U. and A.G.U. wrote the paper with comments from all of the authors. This study was supported by the grants (VTF-12006 and VTF-14027 to AGU and MB, respectively) of Adnan Menderes University. We thank Dr Murat Boyacioglu, Dr Hande Sultan Yalinkilic, Dr Omer Sevim, and Biologist Necati Gunay for technical assistance. We also gratefully thank Ms. Tze-Min Lin for correcting the English grammar mistakes of the manuscript.en_US
dc.language.isoengen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.isversionof10.1097/MBC.0000000000000713en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaortaen_US
dc.subjectex vivoen_US
dc.subjecthemostatic factorsen_US
dc.subjectmouseen_US
dc.subjectobesityen_US
dc.subjectvascular dysfunctionen_US
dc.titleMice with diet-induced obesity demonstrate a relative prothrombotic factor profile and a thicker aorta with reduced ex-vivo functionen_US
dc.typearticleen_US
dc.relation.journalBLOOD COAGULATION & FIBRINOLYSISen_US
dc.contributor.department[Uner, Aykut G. -- Unsal, Cengiz -- Unsal, Humeyra -- Erdogan, Mumin A. -- Koc, Ece -- Ekici, Mehmet -- Balkaya, Muharrem -- Belge, Ferda -- Tarin, Lokman] Adnan Menderes Univ, Fac Vet Med, Dept Physiol, TR-09010 Aydin, Turkey -- [Avci, Hamdi] Adnan Menderes Univ, Fac Vet Med, Dept Pathol, Aydin, Turkey -- [Ekici, Mehmet] Cumhuriyet Univ, Dept Physiol, Fac Vet Med, Sivas, Turkey -- [Erdogan, Mumin A.] Katip Celebi Univ, Dept Physiol, Fac Med, Izmir, Turkeyen_US
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.endpage266en_US
dc.identifier.startpage257en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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