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dc.contributor.authorCakmak, Erol
dc.contributor.authorKarakus, Savas
dc.contributor.authorDemirpence, Ozlem
dc.contributor.authorCoskun, Banu Demet
dc.descriptionWOS: 000426212000002en_US
dc.descriptionPubMed ID: 29476685en_US
dc.description.abstractBackground: This study aimed to investigate ovarian reserve in patients of reproductive age with Celiac disease (CD) using anti-Mullerian hormone (AMH) levels, antral follicle counts (AFCs), and ovarian volume. Material/Methods: We included into this study 46 CD female patients and 40 healthy female subjects of reproductive age, ages 18-45 years. Venous blood samples were taken from both groups on days 2-4 of the menstrual cycle, and follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E-2), prolactin (PRL), and AMH levels were measured. On the same day, AFCs and ovarian volumes were determined. Data on body mass index (BMI), gravidity/parity/abortions/alive counts, disease duration, and Marsh histological classification were recorded. Results: There were no statistically significant differences between CD and control groups in terms of mean age, BMI, or median gravidity/parity/abortions/alive counts (p>0.05). Also, there were no statistically significant differences between the 2 groups in terms of mean FSH, LH, E-2, PRL levels, right and left ovarian volumes, and median right and left ovarian AFCs (p>0.05). However, AMH level was significantly lower in the CD group (p=0.032). No statistically significant correlation was found between AMH levels and age, BMI, FSH, LH, E-2, PRL levels, right and left ovarian volumes, right and left ovarian AFCs, or Marsh histological classification using the Spearman correlation test (p>0.05). However, an inverse correlation was detected showing that AMH levels decrease with increasing CD duration (r=-0.054, p=0.001). Conclusions: We found that AMH level and ovarian reserve was decreased in CD patients of reproductive age compared to healthy controls, and that AMH level and ovarian reserve decreased with increasing disease duration in CD patients.en_US
dc.subjectAnti-Mullerian Hormoneen_US
dc.subjectCeliac Diseaseen_US
dc.titleOvarian Reserve Assessment in Celiac Patients of Reproductive Ageen_US
dc.relation.journalMEDICAL SCIENCE MONITORen_US
dc.contributor.department[Cakmak, Erol] Cumhuriyet Univ, Dept Gastroenterol, Fac Med, Sivas, Turkey -- [Karakus, Savas] Cumhuriyet Univ, Dept Obstet & Gynecol, Fac Med, Sivas, Turkey -- [Demirpence, Ozlem] Cumhuriyet Univ, Dept Biochem, Fac Med, Sivas, Turkey -- [Coskun, Banu Demet] Kayseri Training & Res Hosp, Dept Gastroenterol, Kayseri, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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