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dc.contributor.authorGemici, Aliihsan
dc.contributor.authorAydogdu, Ismet
dc.contributor.authorTerzi, Hatice
dc.contributor.authorSencan, Mehmet
dc.contributor.authorAslan, Alma
dc.contributor.authorKaya, Ali Hakan
dc.contributor.authorDal, Mehmet Sinan
dc.contributor.authorAkay, Meltem Olga
dc.contributor.authorDogu, Mehmet Hilmi
dc.contributor.authorAyyildiz, Orhan
dc.contributor.authorSahin, Fahri
dc.contributor.authorCagliyan, Gulsum Akgun
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorGokgoz, Zafer
dc.contributor.authorBilen, Yusuf
dc.contributor.authorDemir, Cengiz
dc.contributor.authorSevindik, Omur Gokmen
dc.contributor.authorKorkmaz, Serdal
dc.contributor.authorEser, Bulent
dc.contributor.authorAltuntas, Fevzi
dc.descriptionWOS: 000425633300017en_US
dc.descriptionPubMed ID: 28707314en_US
dc.description.abstractNodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a rare subtype of Hodgkin's lymphoma. In this study, we aimed to investigate the clinical features and therapeutic outcomes of patients with NLPHL who were diagnosed at different institutes in Turkey. We retrospectively reviewed the records of the patients diagnosed with NLPHL. Adult patients who were diagnosed after 2005 with histological confirmation were selected for the study. Forty-three patients were included in the study. Median age of patients was 37.5years (18-70) at the time of diagnosis. About 60.5% patients were diagnosed as stage I and II NLPHL, and remaining 39.5% had stage III and IV disease. Median follow-up was 46months. During follow-up, none of the patients died. Seven patients relapsed or progressed after initial therapy at a median of 12months. Five of 7 relapsed/refractory patients (71.4%) were salvaged with chemotherapy only (DHAP, ICE), and the remaining 2 (28.6%) were salvaged with chemoimmunotherapy. All of relapsed/refractory patients were able to achieve complete remission after salvage therapy. Lactate dehydrogenase levels were significantly higher in patients with progressive disease compared with nonprogressive disease. Our study showed an excellent outcome with all patients alive at last contact with a median follow up of 46months despite a wide range of different therapeutic approaches. All relapsed and refractory patients were successfully salvaged despite a low frequency of patients received immunotherapy in conjunction with chemotherapy. Our results suggest that immunotherapy may be reserved for further relapses.en_US
dc.subjectnodular lymphocyte predominant Hodgkin's lymphomaen_US
dc.subjectoverall survivalen_US
dc.subjectprogression-free survivalen_US
dc.titleNodular lymphocyte predominant Hodgkin's lymphoma in daily practice: A multicenter experienceen_US
dc.relation.journalHEMATOLOGICAL ONCOLOGYen_US
dc.contributor.department[Gemici, Aliihsan] Sanliurfa Mehmet AkifInan Training & Res Hosp, Div Hematol, Sanliurfa, Turkey -- [Aydogdu, Ismet] Celal Bayar Univ, Dept Hematol, Manisa, Turkey -- [Terzi, Hatice -- Sencan, Mehmet] Cumhuriyet Univ, Dept Hematol, Sivas, Turkey -- [Aslan, Alma] Hacettepe Univ, Dept Med Oncol, Ankara, Turkey -- [Kaya, Ali Hakan -- Dal, Mehmet Sinan -- Altuntas, Fevzi] Ankara Oncol Training & Res Hosp, Hematol & Stem Cell Transplantat Clin, Ankara, Turkey -- [Akay, Meltem Olga] Osmangazi Univ, Dept Hematol, Eskisehir, Turkey -- [Dogu, Mehmet Hilmi] Istanbul Training & Res Hosp, Div Hematol, Istanbul, Turkey -- [Ayyildiz, Orhan] Dicle Univ, Dept Hematol, Diyarbakir, Turkey -- [Sahin, Fahri] Ege Univ, Dept Hematol, Izmir, Turkey -- [Cagliyan, Gulsum Akgun] Denizli State Hosp, Div Hematol, Denizli, Turkey -- [Yilmaz, Mehmet] Gaziantep Univ, Dept Hematol, Gaziantep, Turkey -- [Gokgoz, Zafer] Ordu State Hosp, Div Hematol Ordu, Ordu, Turkey -- [Bilen, Yusuf] Ataturk Univ, Dept Hematol, Erzurum, Turkey -- [Demir, Cengiz] Yuzuncu Yil Univ, Dept Hematol, Van, Turkey -- [Sevindik, Omur Gokmen] Firat Univ, Dept Hematol, Elazig, Turkey -- [Korkmaz, Serdal] Kayseri Training & Res Hosp, Div Hematol, Kayseri, Turkey -- [Eser, Bulent] Erciyes Univ, Dept Hematol, Kayseri, Turkeyen_US
dc.contributor.authorIDAltuntas, Fevzi -- 0000-0001-6872-3780en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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