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dc.contributor.authorCheung, Angel
dc.contributor.authorGong, Mengqi
dc.contributor.authorBellanti, Roberto
dc.contributor.authorAli-Hasan-Al-Saegh, Sadeq
dc.contributor.authorLi, Guangping
dc.contributor.authorRoig, Eulalia
dc.contributor.authorNunez, Julio
dc.contributor.authorStamos, Thomas D.
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorHakki, Kaya
dc.contributor.authorWu, William K. K.
dc.contributor.authorWong, Sunny Hei
dc.contributor.authorWong, Wing Tak
dc.contributor.authorBazoukis, George
dc.contributor.authorLampropoulos, Konstantinos
dc.contributor.authorTse, Lah Ah
dc.contributor.authorZhao, Jichao
dc.contributor.authorLip, Gregory Y. H.
dc.contributor.authorBaranchuk, Adrian
dc.contributor.authorWong, Martin C. S.
dc.contributor.authorLiu, Tong
dc.contributor.authorTse, Gary
dc.descriptionWOS: 000458034100002en_US
dc.description.abstractBackground Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF. Methods PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels. Results A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I-2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I-2: 84%). Conclusion Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.en_US
dc.description.sponsorshipCroucher Foundation of Hong Kong [81570298]; National Natural Science Foundation of Chinaen_US
dc.description.sponsorshipGT and SHW are supported by the Croucher Foundation of Hong Kong. This work was supported by a research grant (Number: 81570298) from the National Natural Science Foundation of China to TL.en_US
dc.titleCancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysisen_US
dc.relation.journalHEART ASIAen_US
dc.contributor.department[Cheung, Angel] Brown Univ, Dept Biomed Engn, Providence, RI 02912 USA -- [Gong, Mengqi -- Li, Guangping -- Liu, Tong] Tianjin Med Univ, Dept Cardiol, Tianjin Key Lab Ion Mol Funct Cardiovasc Dis, Tianjin Inst Cardiol,Hosp 2, Tianjin, Peoples R China -- [Bellanti, Roberto] Cambridge Univ Hosp NHS Trust, Dept Med, Cambridge, England -- [Ali-Hasan-Al-Saegh, Sadeq] Shahid Sadoughi Univ Med Sci, Cardiovasc Res Ctr, Yazd, Iran -- [Roig, Eulalia] Hosp Santa Creu & Sant Pau, Inst Recerca Biomed St Pau, Cardiol Dept, Barcelona, Spain -- [Roig, Eulalia] Univ Autonoma Barcelona, Barcelona, Spain -- [Nunez, Julio] Univ Valencia, Cardiol Dept, Dept Med, Hosp Clin Univ, Valencia, Spain -- [Nunez, Julio] CIBER Cardiovasc Dis CIBERCV, Madrid, Spain -- [Stamos, Thomas D.] Univ Illinois, Dept Cardiol, Chicago, IL USA -- [Yilmaz, Mehmet Birhan -- Hakki, Kaya] Cumhuriyet Univ, Dept Cardiol, Med Sch, Sivas, Turkey -- [Wu, William K. K.] Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Fac Med, Hong Kong, Peoples R China -- [Wu, William K. K. -- Wong, Sunny Hei -- Tse, Gary] Chinese Univ Hong Kong, Fac Med, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China -- [Wong, Sunny Hei -- Tse, Gary] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Hong Kong, Peoples R China -- [Wong, Wing Tak] Chinese Univ Hong Kong, Sch Life Sci, Hong Kong, Peoples R China -- [Bazoukis, George -- Lampropoulos, Konstantinos] Evangelismos Gen Hosp Athens, Dept Cardiol 2, Lab Cardiac Electrophysiol, Athens, Greece -- [Tse, Lah Ah] Chinese Univ Hong Kong, Div Occupat & Environm Hlth, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China -- [Zhao, Jichao] Univ Auckland, Auckland Bioengn Inst, Auckland, New Zealand -- [Lip, Gregory Y. H.] Univ Birmingham, Inst Cardiovasc Sci, Birmingham, W Midlands, England -- [Lip, Gregory Y. H.] Aalborg Univ, Aalborg Thrombosis Res Unit, Dept Clin Med, Aalborg, Denmark -- [Baranchuk, Adrian] Queens Univ, Div Cardiol, Kingston Gen Hosp, Kingston, ON, Canada -- [Wong, Martin C. S.] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R Chinaen_US
dc.contributor.authorIDWong, Martin -- 0000-0001-7706-9370; Tse, Gary -- 0000-0001-5510-1253en_US

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