Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis
dc.contributor.author | Cheung, Angel | |
dc.contributor.author | Gong, Mengqi | |
dc.contributor.author | Bellanti, Roberto | |
dc.contributor.author | Ali-Hasan-Al-Saegh, Sadeq | |
dc.contributor.author | Li, Guangping | |
dc.contributor.author | Roig, Eulalia | |
dc.contributor.author | Nunez, Julio | |
dc.contributor.author | Stamos, Thomas D. | |
dc.contributor.author | Yilmaz, Mehmet Birhan | |
dc.contributor.author | Hakki, Kaya | |
dc.contributor.author | Wu, William K. K. | |
dc.contributor.author | Wong, Sunny Hei | |
dc.contributor.author | Wong, Wing Tak | |
dc.contributor.author | Bazoukis, George | |
dc.contributor.author | Lampropoulos, Konstantinos | |
dc.contributor.author | Tse, Lah Ah | |
dc.contributor.author | Zhao, Jichao | |
dc.contributor.author | Lip, Gregory Y. H. | |
dc.contributor.author | Baranchuk, Adrian | |
dc.contributor.author | Wong, Martin C. S. | |
dc.contributor.author | Liu, Tong | |
dc.contributor.author | Tse, Gary | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:38:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:38:49Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2398-5968 | |
dc.identifier.issn | 1759-1104 | |
dc.identifier.uri | https://dx.doi.org/10.1136/heartasia-2017-010970 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6421 | |
dc.description | WOS: 000458034100002 | en_US |
dc.description.abstract | Background Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF. Methods PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels. Results A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I-2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I-2: 84%). Conclusion Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies. | en_US |
dc.description.sponsorship | Croucher Foundation of Hong Kong [81570298]; National Natural Science Foundation of China | en_US |
dc.description.sponsorship | GT and SHW are supported by the Croucher Foundation of Hong Kong. This work was supported by a research grant (Number: 81570298) from the National Natural Science Foundation of China to TL. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMJ PUBLISHING GROUP | en_US |
dc.relation.isversionof | 10.1136/heartasia-2017-010970 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis | en_US |
dc.type | review | en_US |
dc.relation.journal | HEART ASIA | en_US |
dc.contributor.department | [Cheung, Angel] Brown Univ, Dept Biomed Engn, Providence, RI 02912 USA -- [Gong, Mengqi -- Li, Guangping -- Liu, Tong] Tianjin Med Univ, Dept Cardiol, Tianjin Key Lab Ion Mol Funct Cardiovasc Dis, Tianjin Inst Cardiol,Hosp 2, Tianjin, Peoples R China -- [Bellanti, Roberto] Cambridge Univ Hosp NHS Trust, Dept Med, Cambridge, England -- [Ali-Hasan-Al-Saegh, Sadeq] Shahid Sadoughi Univ Med Sci, Cardiovasc Res Ctr, Yazd, Iran -- [Roig, Eulalia] Hosp Santa Creu & Sant Pau, Inst Recerca Biomed St Pau, Cardiol Dept, Barcelona, Spain -- [Roig, Eulalia] Univ Autonoma Barcelona, Barcelona, Spain -- [Nunez, Julio] Univ Valencia, Cardiol Dept, Dept Med, Hosp Clin Univ, Valencia, Spain -- [Nunez, Julio] CIBER Cardiovasc Dis CIBERCV, Madrid, Spain -- [Stamos, Thomas D.] Univ Illinois, Dept Cardiol, Chicago, IL USA -- [Yilmaz, Mehmet Birhan -- Hakki, Kaya] Cumhuriyet Univ, Dept Cardiol, Med Sch, Sivas, Turkey -- [Wu, William K. K.] Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Fac Med, Hong Kong, Peoples R China -- [Wu, William K. K. -- Wong, Sunny Hei -- Tse, Gary] Chinese Univ Hong Kong, Fac Med, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China -- [Wong, Sunny Hei -- Tse, Gary] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Hong Kong, Peoples R China -- [Wong, Wing Tak] Chinese Univ Hong Kong, Sch Life Sci, Hong Kong, Peoples R China -- [Bazoukis, George -- Lampropoulos, Konstantinos] Evangelismos Gen Hosp Athens, Dept Cardiol 2, Lab Cardiac Electrophysiol, Athens, Greece -- [Tse, Lah Ah] Chinese Univ Hong Kong, Div Occupat & Environm Hlth, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China -- [Zhao, Jichao] Univ Auckland, Auckland Bioengn Inst, Auckland, New Zealand -- [Lip, Gregory Y. H.] Univ Birmingham, Inst Cardiovasc Sci, Birmingham, W Midlands, England -- [Lip, Gregory Y. H.] Aalborg Univ, Aalborg Thrombosis Res Unit, Dept Clin Med, Aalborg, Denmark -- [Baranchuk, Adrian] Queens Univ, Div Cardiol, Kingston Gen Hosp, Kingston, ON, Canada -- [Wong, Martin C. S.] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China | en_US |
dc.contributor.authorID | Wong, Martin -- 0000-0001-7706-9370; Tse, Gary -- 0000-0001-5510-1253 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 1 | en_US |
dc.relation.publicationcategory | Diğer | en_US |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |
This item appears in the following Collection(s)
-
Diğer Yayınlar Koleksiyonu [403]
Other Publications Collection -
Diğer Yayınlar Koleksiyonu [344]
Other Publications Collection -
Öksüz Yayınlar Koleksiyonu - WoS [6162]