dc.contributor.author | Ozer, Hidir | |
dc.contributor.author | Bozkurt, Huseyin | |
dc.contributor.author | Bozkurt, Gokhan | |
dc.contributor.author | Demirbilek, Murat | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:38:59Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:38:59Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0020-7454 | |
dc.identifier.issn | 1563-5279 | |
dc.identifier.uri | https://dx.doi.org/10.1080/00207454.2018.1435536 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6451 | |
dc.description | WOS: 000437345100006 | en_US |
dc.description | PubMed ID: 29384433 | en_US |
dc.description.abstract | Objectives: A number of chemical and biological factors, including mesenchymal stem cells (MSCs), have been developed to enhance nerve regeneration by introduction through a variety of nerve conduits. This study was designed to assess the efficacy of using chitosan-coated poly-3-hydroxybutyrate (PHB) nerve conduits seeded with human bone marrow-derived MSCs (hMSC-bm) to augment repair in an experimental rat model of sciatic nerve injury.Methods: A total of 30 rats were randomly assigned to one of three groups (n = 10). In each rat, a 10mm segment of the sciatic nerve was removed and was replaced by a chitosan-coated PHB conduit seeded with hMSC-bm (PHB/chitosan-hMSC-bm group), a chitosan-coated PHB conduit (PHB/chitosan group), or an autograft (autograft group) as the control. The results were evaluated 8 weeks postoperatively by observation, electromyography and histologic examination with light microscopy and immunostaining.Results: Histologic examination showed that both PHB/chitosan-hMSC-bm conduits and PHB/chitosan conduits led the damaged axons through the injured area. When the effects were compared, the results with the PHB/chitosan-hMSC-bm conduits were superior to those with the PHB/chitosan conduits (p < 0.05) but not as successful as with the autologous nerve grafts (p < 0.05).Conclusion: PHB/chitosan-hMSC-bm nerve conduits may be a useful artificial guide for nerve regeneration. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.relation.isversionof | 10.1080/00207454.2018.1435536 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Chitosan | en_US |
dc.subject | stem cell | en_US |
dc.subject | sciatic nerve regeneration | en_US |
dc.title | Regenerative potential of chitosan-coated poly-3-hydroxybutyrate conduits seeded with mesenchymal stem cells in a rat sciatic nerve injury model | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF NEUROSCIENCE | en_US |
dc.contributor.department | [Ozer, Hidir] Hacettepe Univ, Fac Med, Dept Neurosurg, Ankara, Turkey -- [Bozkurt, Huseyin] Cumhuriyet Univ, Fac Med, Dept Neurosurg, Sivas, Turkey -- [Bozkurt, Gokhan] Mem Private Hosp, Dept Neurosurg, Ankara, Turkey -- [Demirbilek, Murat] Hacettepe Univ, Adv Technol Applicat & Res Ctr, Ankara, Turkey | en_US |
dc.contributor.authorID | BOZKURT, HUSEYIN -- 0000-0001-6432-5371; OZER, HIDIR -- 0000-0002-1017-2389 | en_US |
dc.identifier.volume | 128 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.endpage | 834 | en_US |
dc.identifier.startpage | 828 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |