dc.contributor.author | Ucar, Esra | |
dc.contributor.author | Eruygur, Nuraniye | |
dc.contributor.author | Atas, Mehmet | |
dc.contributor.author | Ergul, Merve | |
dc.contributor.author | Ergul, Mustafa | |
dc.contributor.author | Sozmen, Fazli | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:39:12Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:39:12Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0145-5680 | |
dc.identifier.issn | 1165-158X | |
dc.identifier.uri | https://dx.doi.org/10.14715/cmb/2018.64.11.3 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6487 | |
dc.description | WOS: 000444259700003 | en_US |
dc.description | PubMed ID: 30213283 | en_US |
dc.description.abstract | Plane tree (Platanus orientalis L.) leaves have been employed for centuries in various countries due to their pharmacological value. Therefore, determination of the biological activity of the leaves is of interest. The aim of the study was to evaluate the inhibitory effects against Alzheimer's disease-related enzymes Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE), diabetes mellitus related enzymes alpha-glucosidase and alpha-amylase. The antioxidant, anticancer, and antimicrobial activities of the leaves were also studied. According to the results, both water and methanol extracts of P. orientalis demonstrated more alpha-glucosidase and alpha-amylase inhibition activity than the antidiabetic drug-acarbose at the same concentration level. In addition, extracts showed good inhibition activity against AChE and BuChE. Significant results were obtained regarding antioxidant, anticancer, and antimicrobial activities. These results are very promising especially for the improvement of pharmaceutical formulations to treat various diseases such as age-related diseases, cancer, diabetes etc. and it is necessary to conduct further experiments. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | C M B ASSOC | en_US |
dc.relation.isversionof | 10.14715/cmb/2018.64.11.3 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Plane tree | en_US |
dc.subject | Alzheimer's Disease | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Antioxidant Activity | en_US |
dc.subject | Cytotoxic and Antimicrobial activities | en_US |
dc.title | Determination of inhibitory activities of enzymes, related to Alzheimer's disease and diabetes mellitus of plane tree (Platanus orientalis L.) extracts and their antioxidant, antimicrobial and anticancer activities | en_US |
dc.type | article | en_US |
dc.relation.journal | CELLULAR AND MOLECULAR BIOLOGY | en_US |
dc.contributor.department | [Ucar, Esra] Cumhuriyet Univ, Vocat Sch, Med & Aromat Plant Dept, TR-58140 Sivas, Turkey -- [Eruygur, Nuraniye] Selcuk Univ, Fac Phannacy, Pharmacognosy Dept, TR-42250 Konya, Turkey -- [Atas, Mehmet] Cumhuriyet Univ, Fac Pharm, Pharmaceut Microbiol Dept, TR-58140 Sivas, Turkey -- [Ergul, Merve] Cumhuriyet Univ, Fac Pharm, Pharmacol Dept, TR-58140 Sivas, Turkey -- [Ergul, Mustafa] Cumhuriyet Univ, Fac Phannacy, Biochem Dept, TR-58140 Sivas, Turkey -- [Sozmen, Fazli] Cumhuriyet Univ, Fac Engn, Nanotechnol Engn Dept, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Ergul, Mustafa -- 0000-0003-4303-2996 | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.endpage | 19 | en_US |
dc.identifier.startpage | 13 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |