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dc.contributor.authorUcar, Esra
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAtas, Mehmet
dc.contributor.authorErgul, Merve
dc.contributor.authorErgul, Mustafa
dc.contributor.authorSozmen, Fazli
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:39:12Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:39:12Z
dc.date.issued2018
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.urihttps://dx.doi.org/10.14715/cmb/2018.64.11.3
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6487
dc.descriptionWOS: 000444259700003en_US
dc.descriptionPubMed ID: 30213283en_US
dc.description.abstractPlane tree (Platanus orientalis L.) leaves have been employed for centuries in various countries due to their pharmacological value. Therefore, determination of the biological activity of the leaves is of interest. The aim of the study was to evaluate the inhibitory effects against Alzheimer's disease-related enzymes Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE), diabetes mellitus related enzymes alpha-glucosidase and alpha-amylase. The antioxidant, anticancer, and antimicrobial activities of the leaves were also studied. According to the results, both water and methanol extracts of P. orientalis demonstrated more alpha-glucosidase and alpha-amylase inhibition activity than the antidiabetic drug-acarbose at the same concentration level. In addition, extracts showed good inhibition activity against AChE and BuChE. Significant results were obtained regarding antioxidant, anticancer, and antimicrobial activities. These results are very promising especially for the improvement of pharmaceutical formulations to treat various diseases such as age-related diseases, cancer, diabetes etc. and it is necessary to conduct further experiments.en_US
dc.language.isoengen_US
dc.publisherC M B ASSOCen_US
dc.relation.isversionof10.14715/cmb/2018.64.11.3en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlane treeen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectDiabetesen_US
dc.subjectAntioxidant Activityen_US
dc.subjectCytotoxic and Antimicrobial activitiesen_US
dc.titleDetermination of inhibitory activities of enzymes, related to Alzheimer's disease and diabetes mellitus of plane tree (Platanus orientalis L.) extracts and their antioxidant, antimicrobial and anticancer activitiesen_US
dc.typearticleen_US
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGYen_US
dc.contributor.department[Ucar, Esra] Cumhuriyet Univ, Vocat Sch, Med & Aromat Plant Dept, TR-58140 Sivas, Turkey -- [Eruygur, Nuraniye] Selcuk Univ, Fac Phannacy, Pharmacognosy Dept, TR-42250 Konya, Turkey -- [Atas, Mehmet] Cumhuriyet Univ, Fac Pharm, Pharmaceut Microbiol Dept, TR-58140 Sivas, Turkey -- [Ergul, Merve] Cumhuriyet Univ, Fac Pharm, Pharmacol Dept, TR-58140 Sivas, Turkey -- [Ergul, Mustafa] Cumhuriyet Univ, Fac Phannacy, Biochem Dept, TR-58140 Sivas, Turkey -- [Sozmen, Fazli] Cumhuriyet Univ, Fac Engn, Nanotechnol Engn Dept, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDErgul, Mustafa -- 0000-0003-4303-2996en_US
dc.identifier.volume64en_US
dc.identifier.issue11en_US
dc.identifier.endpage19en_US
dc.identifier.startpage13en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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