Show simple item record

dc.contributor.authorCalisir, Metin
dc.contributor.authorAkpinar, Aysun
dc.contributor.authorTalmac, Ahmet Cemil
dc.contributor.authorAlpan, Aysan Lektemur
dc.contributor.authorGoze, Omer Fahrettin
dc.descriptionWOS: 000441578900001en_US
dc.descriptionPubMed ID: 30154905en_US
dc.description.abstractIntroduction. Humic acid was previously shown to enhance cutaneous wound healing and show antibacterial properties; however, it has not been used for wound healing in the oral cavity. Thus, the goal of this study was the evaluation of the effect of the humic acid on the healing of excisional wounds in an experimental rat study. Materials and Methods. A circular wound on mid-palatal surfaces was made on a total of 77 Wistar rats by using a 3-mm biopsy punch under anesthesia. The animals were divided into 4 groups as baseline, saline control (0.09%), chlorhexidine gluconate (0.05%), and humic acid (80 mg/kg) and were treated with these materials for 7 days. Results. The rats were observed for 3 weeks in order to track the wound closure rates. Both humic acid treatment and chlorhexidine gluconate treatment resulted in statistically significant enhanced rate of wound closure compared to the saline control on both the 1st and 2nd weeks of treatment. Humic acid treatment for the wounds in the palate resulted in enhanced recovery compared to not only saline control but also chlorhexidine gluconate treatment. Conclusion. In this study, humic acid was shown to enhance healing of oral wounds for the first time in the literature. These findings indicate that humic acid can be used as an alternative to current treatment methods for oral wounds.en_US
dc.publisherHINDAWI LTDen_US
dc.titleHumic Acid Enhances Wound Healing in the Rat Palateen_US
dc.contributor.department[Calisir, Metin] Adiyaman Univ, Fac Dent, Dept Periodontol, Adiyaman, Turkey -- [Akpinar, Aysun] Cumhuriyet Univ, Fac Dent, Dept Periodontol, Sivas, Turkey -- [Talmac, Ahmet Cemil] Yuzuncu Yil Univ, Fac Dent, Dept Periodontol, Van, Turkey -- [Alpan, Aysan Lektemur] Pamukkale Univ, Fac Dent, Dept Periodontol, Denizli, Turkey -- [Goze, Omer Fahrettin] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkeyen_US
dc.contributor.authorIDCalisir, Metin -- 0000-0001-6607-6532; LEKTEMUR ALPAN, AYSAN -- 0000-0002-5939-4783en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record