dc.contributor.author | Bolayir, Hasan Ata | |
dc.contributor.author | Kivrak, Tarik | |
dc.contributor.author | Gunes, Hakan | |
dc.contributor.author | Bolayir, Asli | |
dc.contributor.author | Karaca, Ilgin | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:39:26Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:39:26Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0022-9032 | |
dc.identifier.issn | 1897-4279 | |
dc.identifier.uri | https://dx.doi.org/10.5603/KP.2018.0006 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6529 | |
dc.description | WOS: 000430041800012 | en_US |
dc.description | PubMed ID: 29313563 | en_US |
dc.description.abstract | Background: Nocturnal hypertension and non-dipping pattern are often associated with endothelial dysfunction. Previous studies suggested that adropin, a novel secreted energy homeostasis protein, has the unique ability to regulate endothelial cell function. Aim: This study aims to investigate the association between absolute night-time blood pressure (BP) and circadian BP pattern with serum adropin and high-sensitivity C-reactive protein (hsCRP) levels in patients with newly diagnosed untreated arterial hypertension. Methods: Twenty-four-hour ambulatory BP monitoring was recorded in 100 hypertensives (50 dippers, 50 non-dippers) and 50 healthy controls. Serum levels of adropin and hsCRP were measured and recorded. Results: A strong correlation was found between night-time BP levels with adropin and hsCRP levels (p < 0.001). On the other hand, the non-dipper group demonstrated lower adropin levels compared to the dipper and normotensive groups: non dipper group, 2580 +/- 457 pg/mL; dipper group, 3298 +/- 530 pg/mL; normotensive group, 3681 +/- 411 pg/mL; p < 0.001). HsCRP levels were significantly higher in the non-dipper group than in the two other groups (p = 0.017). In a multivariate logistic regression analysis, adropin (p = 0.012) and hsCRP (p = 0.039) were independently associated with a non-dipping pattern. Conclusions: Decreased adropin levels were found in the nocturnal hypertensive and non-dipper groups. Adropin and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that decreased levels of adropin in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to a possible future role of adropin in identifying hypertensive patients at higher risk of target organ damage. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | VIA MEDICA | en_US |
dc.relation.isversionof | 10.5603/KP.2018.0006 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | adropin | en_US |
dc.subject | high-sensitivity C-reactive protein | en_US |
dc.subject | dipper | en_US |
dc.subject | non-dipper hypertension | en_US |
dc.title | Adropin and circadian variation of blood pressure | en_US |
dc.type | article | en_US |
dc.relation.journal | KARDIOLOGIA POLSKA | en_US |
dc.contributor.department | [Bolayir, Hasan Ata -- Kivrak, Tarik -- Gunes, Hakan] Sivas Numune Hosp, Cardiol Dept, Sivas, Turkey -- [Bolayir, Asli] Cumhuriyet Univ, Dept Neurol, Sivas, Turkey -- [Karaca, Ilgin] Firat Univ, Cardiol Dept, Elazig, Turkey | en_US |
dc.identifier.volume | 76 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 782 | en_US |
dc.identifier.startpage | 776 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |