Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer
dc.contributor.author | Celik, V. Kenan | |
dc.contributor.author | Kapancik, Sercan | |
dc.contributor.author | Kacan, Turgut | |
dc.contributor.author | Kacan, Selen Baloglu | |
dc.contributor.author | Kapancik, Serkan | |
dc.contributor.author | Kilicgun, Hasan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:39:57Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:39:57Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2049-3614 | |
dc.identifier.uri | https://dx.doi.org/10.1530/EC-17-0137 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6609 | |
dc.description | WOS: 000418497500006 | en_US |
dc.description | PubMed ID: 28870974 | en_US |
dc.description.abstract | Background: In this study, it was aimed to investigate the relationship between diabetes and breast cancer and the detection of enzymes and ornithine levels in polyamine synthesis pathway in diabetes, breast cancer and diabetic breast cancer patients. Methods: Ornithine, arginine decarboxylase, ornithine decarboxylase and agmatinase levels have been measured in serum of all groups. Ornithine levels were measured spectrophotometrically. Arginine decarboxylase, ornithine decarboxylase and agmatinase levels were determined by ELISA kits. Results: Except for the diabetic group, the levels of enzymes in the polyamine synthesis pathway were increased in all and statistically significant (P < 0.05). The increase in the levels of agmatinase was very important among the enzymes (P < 0.001). Conclusions: Decreased levels of polyamine synthase enzymes in diabetes mellitus were found to be increased patients with breast cancer. Whether and how diabetes-based breast cancer development relates to increase activity of enzymes responsible for polyamine synthesis requires further mechanistic and prospective monitoring studies in larger patient cohorts. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BIOSCIENTIFICA LTD | en_US |
dc.relation.isversionof | 10.1530/EC-17-0137 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | diabetes | en_US |
dc.subject | breast cancer | en_US |
dc.subject | polyamines | en_US |
dc.subject | ornithine | en_US |
dc.title | Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | ENDOCRINE CONNECTIONS | en_US |
dc.contributor.department | [Celik, V. Kenan -- Kapancik, Sercan -- Kapancik, Serkan] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Kacan, Turgut] High Specialized Educ & Res Hosp, Dept Med Oncol, Bursa, Turkey -- [Kacan, Selen Baloglu] Afyonkarahisar State Hosp, Dept Internal Med, Afyon, Turkey -- [Kilicgun, Hasan] Univ Erzincan, Hlth Sci Fac, Dept Nutr & Dietet, Erzincan, Turkey | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.endpage | 579 | en_US |
dc.identifier.startpage | 574 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |
This item appears in the following Collection(s)
-
Makale Koleksiyonu [5200]
Article Collection -
Makale Koleksiyonu [5745]
Article Collection -
Öksüz Yayınlar Koleksiyonu - WoS [6162]