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dc.contributor.authorTas, Ayca
dc.contributor.authorAtabey, Mustafa
dc.contributor.authorCaglayan, Gulcin
dc.contributor.authorBostanci, Meric Emre
dc.contributor.authorBolukbasi, Serap Sahin
dc.contributor.authorTopcu, Omer
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:39:58Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:39:58Z
dc.date.issued2017
dc.identifier.issn2049-9434
dc.identifier.issn2049-9442
dc.identifier.urihttps://dx.doi.org/10.3892/br.2017.978
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6610
dc.descriptionWOS: 000417416000012en_US
dc.description.abstractMurine double minute clone 2 oncoprotein (MDM2) is a key component in the regulation of the tumour suppressor p53. The association between the MDM2 polymorphism and gastric cancer (GC) has been investigated in Turkish population. In the present case-control study, the aim was to investigate the association between genetic polymorphisms of the MDM2 gene (a major regulator of p53 function) and primary GC risk in a Turkish population. The polymorphism, T309G (rs2279744) in the MDM2 gene was determined in patients with GC (n=65) and in healthy control subjects (n=67) using the polymerase chain reaction-restriction fragment length polymorphism method. The findings were evaluated using logistic regression and.2 tests. No statistically significant differences were observed between the control subjects and patients with GC regarding smoking status. A comparison between GC cases and control subjects indicated a statistically significant difference for family history of cancer [odds ratio (OR)=0.17; 95% confidence interval (CI), 0.05-0.56;.2=0.19; P=0.01]. A significant difference was identified in the GG genotype distribution between GC patients and control subjects (OR=4.58; 95% CI, 1.18-17.79; P=0.022). Thus, the results of the present study indicate that the MDM2 gene T309G intron (GG) genotype may be an important risk factor for GC development in the Turkish population.en_US
dc.description.sponsorshipCumhuriyet University [CUBAP T-547]en_US
dc.description.sponsorshipThis study was funded by Cumhuriyet University (grant no. CUBAP T-547).en_US
dc.language.isoengen_US
dc.publisherSPANDIDOS PUBL LTDen_US
dc.relation.isversionof10.3892/br.2017.978en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgastric canceren_US
dc.subjectpolymorphismen_US
dc.subjectMDM2 gene T309Gen_US
dc.subjectTurkish populationen_US
dc.titleInvestigation of the association between the MDM2 T309G polymorphism and gastric canceren_US
dc.typearticleen_US
dc.relation.journalBIOMEDICAL REPORTSen_US
dc.contributor.department[Tas, Ayca] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Diet, TR-58140 Sivas, Turkey -- [Atabey, Mustafa -- Topcu, Omer] Cumhuriyet Univ, Fac Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Caglayan, Gulcin -- Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Bostanci, Meric Emre] Sivas Sample Hosp, Clin Gen Surg, TR-58060 Sivas, Turkey -- [Bolukbasi, Serap Sahin] Cumhuriyet Univ, Fac Pharmaceut, Dept Biochem, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume7en_US
dc.identifier.issue5en_US
dc.identifier.endpage473en_US
dc.identifier.startpage469en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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