Results of a Multicenter Study Investigating Plasmid Mediated Colistin Resistance Genes (mcr-1 and mcr-2) in Clinical Enterobacteriaceae Isolates from Turkey
dc.contributor.author | Sari, Ayse Nur | |
dc.contributor.author | Suzuk, Serap | |
dc.contributor.author | Karatuna, Onur | |
dc.contributor.author | Ogunc, Dilara | |
dc.contributor.author | Karakoc, Ayse Esra | |
dc.contributor.author | Cizmeci, Zeynep | |
dc.contributor.author | Aliskan, Hikmet Eda | |
dc.contributor.author | Comert, Fsun | |
dc.contributor.author | Bakici, Mustafa Zahir | |
dc.contributor.author | Akpolat, Nezahat | |
dc.contributor.author | Cilli, Fatma Feriha | |
dc.contributor.author | Zer, Yasemin | |
dc.contributor.author | Karatas, Aysel | |
dc.contributor.author | Karapinar, Bahar Akgun | |
dc.contributor.author | Bayramoglu, Gulcin | |
dc.contributor.author | Ozdamar, Melda | |
dc.contributor.author | Kalem, Fatma | |
dc.contributor.author | Delialioglu, Nuran | |
dc.contributor.author | Aktas, Elif | |
dc.contributor.author | Yilmaz, Nisel | |
dc.contributor.author | Gurcan, Saban | |
dc.contributor.author | Gulay, Zeynep | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:40:56Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:40:56Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0374-9096 | |
dc.identifier.uri | https://dx.doi.org/10.5578/mb.57515 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6742 | |
dc.description | WOS: 000408311400011 | en_US |
dc.description | PubMed ID: 28929967 | en_US |
dc.description.abstract | Colistin is a polymyxin antibiotic which is considered as one of the last line agents against infections due to multidrug resistant or carbapenem resistant gram-negative pathogens. Colistin resistance is associated with chromosomal alterations which can usually cause mutations in genes coding specific two component regulator systems. The first plasmid-mediated colistin resistance gene, mcr-1 was described in Escherichia coli and Klebsiella pneumoniae isolates in December 2015 and followed by another plasmid-mediated colistin resistance gene mcr-2 in 2016. The rapid and interspecies dissemination of plasmid-mediated resistance mechanisms through horizontal gene transfer, have made these genes considerably threatening. After the first reports, although mcr-1/mcr-2 producing Enterobacteriaceae isolates have been reported from many countries, there have been no reports from Turkey. Thus, the aim of this study was to investigate the presence of mcr-1/mcr-2 in clinical Enterobacteriaceae isolates from different parts of our country. A total of 329 Enterobacteriaceae isolates from 22 laboratories were collected which were isolated between March, 2015 and February, 2016. mcr-1/mcr-2 were investigated by polymerase chain reaction during February-March, 2016. Two hundred and seventeen of Klebsiella pneumoniae (66%), 75 of Salmonella spp. (22.8%), 31 of Esherichia coli (9.4%), 3 of Enterobacter cloacae (0.9%), 2 of Klebsiella oxytoca (0.6%) and 1 of Enterobacter aerogenes (0.3%) isolates were included to the study. Agarose gel electrophoresis results of PCR studies have shown expected band sizes for positive control isolates as 309 bp for mcr-1 and 567 bp for mcr-2. However, the presence of mcr-1/mcr-2 genes was not detected among the tested study isolates of Enterobacteriaceae. Although mcr-1/mcr-2 were not detected in our study isolates, it is highly important to understand the mechanism of resistance dissemination and determine the resistant isolates by considering that colistin is a last-line antibiotic against infections of multidrug or carbapenem resistant gram-negative bacteria. Thus, it is suggested that these mechanisms should be followed-up in both clinical and non-clinical (e.g. isolates from food animals, raw meats and environment) isolates of special populations. | en_US |
dc.language.iso | tur | en_US |
dc.publisher | ANKARA MICROBIOLOGY SOC | en_US |
dc.relation.isversionof | 10.5578/mb.57515 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Colistin | en_US |
dc.subject | mcr-1 | en_US |
dc.subject | mcr-2 | en_US |
dc.subject | Enterobacteriaceae | en_US |
dc.title | Results of a Multicenter Study Investigating Plasmid Mediated Colistin Resistance Genes (mcr-1 and mcr-2) in Clinical Enterobacteriaceae Isolates from Turkey | en_US |
dc.type | article | en_US |
dc.relation.journal | MIKROBIYOLOJI BULTENI | en_US |
dc.contributor.department | [Sari, Ayse Nur -- Gulay, Zeynep] Dokuz Eylul Univ, Fac Med, Dept Med Microbiol, Izmir, Turkey -- [Sari, Ayse Nur] SANKO Univ, Fac Med, Dept Med Microbiol, Gaziantep, Turkey -- [Suzuk, Serap] Publ Hlth Inst Turkey, Dept Microbiol, Reference Lab, Ankara, Turkey -- [Karatuna, Onur] Acibadem Univ, Fac Med, Dept Med Microbiol, Istanbul, Turkey -- [Ogunc, Dilara] Akdeniz Univ, Fac Med, Dept Med Microbiol, Antalya, Turkey -- [Karakoc, Ayse Esra] Ankara Numune Training & Res Hosp, Dept Med Microbiol, Ankara, Turkey -- [Cizmeci, Zeynep] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Microbiol Lab, Istanbul, Turkey -- [Aliskan, Hikmet Eda] Baskent Univ, Fac Med, Dept Med Microbiol, Adana, Turkey -- [Comert, Fsun] Bulent Ecevit Univ, Fac Med, Dept Med Microbiol, Zonguldak, Turkey -- [Bakici, Mustafa Zahir] Cumhuriyet Univ, Fac Med, Dept Med Microbiol, Sivas, Turkey -- [Akpolat, Nezahat] Dicle Univ, Fac Med, Dept Med Microbiol, Diyarbakir, Turkey -- [Cilli, Fatma Feriha] Ege Univ, Fac Med, Dept Med Microbiol, Izmir, Turkey -- [Zer, Yasemin] Gaziantep Univ, Fac Med, Dept Med Microbiol, Gaziantep, Turkey -- [Karatas, Aysel] Istanbul Training & Res Hosp, Dept Med Microbiol, Istanbul, Turkey -- [Karapinar, Bahar Akgun] Istanbul Univ, Fac Med, Dept Med Microbiol, Istanbul, Turkey -- [Bayramoglu, Gulcin] Karadeniz Tech Univ, Fac Med, Dept Med Microbiol, Trabzon, Turkey -- [Ozdamar, Melda] Anadolu Med Ctr, Microbiol Lab, Kocaeli, Turkey -- [Kalem, Fatma] Konya Numune Hosp, Clin Microbiol Lab, Konya, Turkey -- [Delialioglu, Nuran] Mersin Univ, Fac Med, Dept Med Microbiol, Mersin, Turkey -- [Aktas, Elif] Sisli Hamidiye Etfal Res & Training Hosp, Clin Microbiol Lab, Istanbul, Turkey -- [Yilmaz, Nisel] Tepec Res & Training Hosp, Clin Microbiol Lab, Izmir, Turkey -- [Gurcan, Saban] Trakya Univ, Fac Med, Dept Med Microbiol, Edirne, Turkey | en_US |
dc.contributor.authorID | Ogunc, Dilara -- 0000-0001-6669-6811; aktas, elif -- 0000-0003-3087-5425 | en_US |
dc.identifier.volume | 51 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 303 | en_US |
dc.identifier.startpage | 299 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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