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dc.contributor.authorMert, Kadir U.
dc.contributor.authorMert, Gurbet O.
dc.contributor.authorBasaran, Ozcan
dc.contributor.authorBeton, Osman
dc.contributor.authorDogan, Volkan
dc.contributor.authorTekinalp, Mehmet
dc.contributor.authorAykan, Ahmet C.
dc.contributor.authorKalaycioglu, Ezgi
dc.contributor.authorBolat, Ismail
dc.contributor.authorTasar, Onur
dc.contributor.authorSafak, Ozgen
dc.contributor.authorKalcik, Macit
dc.contributor.authorYaman, Mehmet
dc.contributor.authorKirma, Cevat
dc.contributor.authorBiteker, Murat
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:41:11Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:41:11Z
dc.date.issued2017
dc.identifier.issn0014-2972
dc.identifier.issn1365-2362
dc.identifier.urihttps://dx.doi.org/10.1111/eci.12758
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6774
dc.descriptionWOS: 000402283900004en_US
dc.descriptionPubMed ID: 28407216en_US
dc.description.abstractBackgroundThe data regarding stroke prevention strategies in nonvalvular atrial fibrillation (NVAF) are limited especially in patients with renal impairment (RI). We sought to evaluate management dilemmas in patients with concurrent NVAF and RI in RAMSES (ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies inTurkey) study. MethodsWe conducted a prospective, multicenter, nation-wide registry in NVAF patients in outpatient cardiology clinics. All consecutive patients with NVAF were enrolled in RAMSES study (ClinicalTrials.gov identifier NCT02344901). The baseline data were collected. Glomerular filtration rate (GFR) was estimated by Cockcroft-Gault equation. ResultsA total number of 6273 patients from 29 provinces of Turkey with the contribution of 83 investigators were enrolled to the study. Of the study population, 1964(33%) patients had RI which was defined as GFR < 60 mL/min. Patients with RI had significantly higher CHA(2)DS(2)VASc and HAS-BLED scores compared to those without RI (39 15 vs. 29 +/- 15, and 20 +/- 1 vs. 14 +/- 1; P < 0001). Prior history of major bleeding (69% vs. 41%, P < 0001) and stroke (162% vs. 118%, P < 0001) was significantly higher among individuals with concomitant RI and NVAF. Although RI patients had a higher risk for thromboembolism, number of the patients who did not receive any anticoagulant therapy was higher in patients with RI than without RI (301 vs. 264%, P = 0003). ConclusionRAMSES study showed that one-third of the patients with NVAF had RI in the real-world setting. Although it is mandatory in most of the patients with concomitant NVAF and RI, nearly one-third of these patients did not receive any anticoagulant therapy.en_US
dc.language.isoengen_US
dc.publisherWILEYen_US
dc.relation.isversionof10.1111/eci.12758en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtrium fibrillationen_US
dc.subjectglomerular filtration rateen_US
dc.subjectpreventionen_US
dc.subjectrenal impairmenten_US
dc.subjectstrokeen_US
dc.titleReal-world stroke prevention strategies in nonvalvular atrial fibrillation in patients with renal impairmenten_US
dc.typearticleen_US
dc.relation.journalEUROPEAN JOURNAL OF CLINICAL INVESTIGATIONen_US
dc.contributor.department[Mert, Kadir U.] Eskiehir Osmangazi Univ, Dept Cardiol, Fac Med, Eskisehir, Turkey -- [Mert, Gurbet O.] Eskisehir Yunus Emre State Hosp, Dept Cardiol, Eskisehir, Turkey -- [Basaran, Ozcan -- Dogan, Volkan -- Biteker, Murat] Mugla Sitki Kocman Univ, Dept Cardiol, Fac Med, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet C. -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Mugla, Turkey -- [Tasar, Onur] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- [Yaman, Mehmet] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Educ & Res Hosp, Istanbul, Turkeyen_US
dc.contributor.authorIDBASARAN, OZCAN -- 0000-0002-6384-6455; Demir, Vahit -- 0000-0001-8349-6651; mert, kadir ugur -- 0000-0002-1331-5365en_US
dc.identifier.volume47en_US
dc.identifier.issue6en_US
dc.identifier.endpage438en_US
dc.identifier.startpage428en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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