dc.contributor.author | Ustun, Elvan | |
dc.contributor.author | Ozgur, Aykut | |
dc.contributor.author | Coskun, Kubra A. | |
dc.contributor.author | Dusunceli, Serpil Demir | |
dc.contributor.author | Ozdemir, Ismail | |
dc.contributor.author | Tutar, Yusuf | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:41:21Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:41:21Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0340-4285 | |
dc.identifier.issn | 1572-901X | |
dc.identifier.uri | https://dx.doi.org/10.1007/s11243-017-0136-x | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6796 | |
dc.description | WOS: 000399456900007 | en_US |
dc.description.abstract | Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against tumor formation and survival of cancer cells. In this work, manganese-based CO-releasing molecules (CORMs) were designed and synthesized to inhibit breast cancer cell proliferation. Human invasive ductal breast cancer cells (MCF-7) were treated with the synthesized CORMs to investigate the effect of the complexes on breast cancer survival under UV light. In vitro experiments indicated that the complexes inhibited breast cancer cell proliferation, and further, the antiproliferative effects were increased under UV light. Thus, these novel CORMs may provide a drug template for the treatment of invasive ductal breast cancer. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK) [112T320] | en_US |
dc.description.sponsorship | This work by Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 112T320) is gratefully acknowledged. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/s11243-017-0136-x | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands | en_US |
dc.type | article | en_US |
dc.relation.journal | TRANSITION METAL CHEMISTRY | en_US |
dc.contributor.department | [Ustun, Elvan] Ordu Univ, Fac Art & Sci, Dept Chem, TR-52200 Ordu, Turkey -- [Ozgur, Aykut -- Coskun, Kubra A.] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Bioengn, TR-60100 Tokat, Turkey -- [Dusunceli, Serpil Demir] Inonu Univ, Dept Chem, Fac Sci, TR-44280 Malatya, Turkey -- [Tutar, Yusuf] Cumhuriyet Univ, Div Biochem, Dept Basic Pharmaceut Sci, Fac Pharm, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 42 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 337 | en_US |
dc.identifier.startpage | 331 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |