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dc.contributor.authorErsoy, Gulcin Sahin
dc.contributor.authorEnsari, Tugba Altun
dc.contributor.authorSubas, Seda
dc.contributor.authorGiray, Burak
dc.contributor.authorSimsek, Engin Ersin
dc.contributor.authorCevik, Ozge
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:41:33Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:41:33Z
dc.date.issued2017
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.urihttps://dx.doi.org/10.1080/14767058.2016.1192118
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6819
dc.descriptionWOS: 000399742600012en_US
dc.descriptionPubMed ID: 27267804en_US
dc.description.abstractObjective: To investigate Wnt1-inducible signaling pathway protein-1 (WISP1) levels and their correlation with metabolic parameters in pregnant women with gestational diabetes mellitus (GDM) and non-GDM healthy pregnant women. Materials and Methods: In this prospective cross-sectional study, the study group was composed of 62 women with GDM and 73 healthy pregnant women matched for age, body mass index (BMI) and gestational age. Blood samples were collected at 25-29th gestational week. Serum WISP1, betatrophin, glucose, fasting insulin, glycosylated hemoglobin A1c, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, C reactive protein, alanine aminotransferase and creatinine levels were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) values was calculated. The level of significance was accepted as p<0.05. Results: Circulating WISP1 in the GDM group was significantly higher than the control group (p<0.001). Further, WISP1 was positively correlated with BMI, HOMA-IR values and fasting glucose, fasting insulin, triglyceride, betatrophin levels. BMI, HOMA-IR and betatrophin independently and positively predicted WISP1 levels. Conclusion: These results demonstrate a relationship between WISP1 and the metabolic parameters of GDM. And, WISP1 might be involved in the pathophysiology of GDM. As a part of this pathophysiological mechanism, the activation of WISP1 and betatrophin might take place through several ways; WISP1 and betatrophin might either use same signaling pathways and potentiate each other or they might also constitute the sequential steps of a common pathway.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.isversionof10.1080/14767058.2016.1192118en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBetatrophinen_US
dc.subjectgestational diabetes mellitusen_US
dc.subjectHOMA-IRen_US
dc.subjectWISP1en_US
dc.titleWISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitusen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINEen_US
dc.contributor.department[Ersoy, Gulcin Sahin -- Ensari, Tugba Altun] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA -- [Ersoy, Gulcin Sahin -- Subas, Seda -- Giray, Burak] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Ensari, Tugba Altun] Etlik Zubeyde Hanim Womens Hlth Educ & Res Hosp, Dept Obstet & Gynecol, Ankara, Turkey -- [Simsek, Engin Ersin] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Dept Family Med, Istanbul, Turkey -- [Cevik, Ozge] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkeyen_US
dc.contributor.authorIDCevik, Ozge -- 0000-0002-9325-3757en_US
dc.identifier.volume30en_US
dc.identifier.issue8en_US
dc.identifier.endpage946en_US
dc.identifier.startpage942en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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