dc.contributor.author | Bagda, Esra | |
dc.contributor.author | Yabas, Ebru | |
dc.contributor.author | Bagda, Efican | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:00Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:00Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1386-1425 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.saa.2016.01.019 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6850 | |
dc.description | 39th Colloquium on Spectroscopicum Internationale (CSI) -- AUG 30-SEP 03, 2015 -- New Univ Lisbon, Figueira da Foz, PORTUGAL | en_US |
dc.description | WOS: 000389093000026 | en_US |
dc.description | PubMed ID: 26803444 | en_US |
dc.description.abstract | In the present study a novel water soluble double-decker phthalocyanine was synthesized and calf thymus DNA interaction of the synthesized double-decker phthalocyanine was investigated. 5-(3-pyridyl)-1,3,4-oxadiazole substituted phthalonitrile 1 was prepared by a nucleophilic displacement reaction of 4-nitrophthalonitrile with 5-(3-pyridyl)-1,3,4-oxadiazole-2-thiol. Lutetium(III) double-decker phthalocyanine 2 was prepared by cyclotetramerization of compound 1. Water soluble lutetium(III) double-decker phthalocyanine 3 was prepared with quaternarization of compound 2. The synthesized double-decker phthalocyanine and calf thymus DNA interaction was investigated with UV-vis titrimetric methods, gel electrophoresis, and viscosity measurements. The fluorometric ethidium bromide replacement assay was conducted to clarify the binding mode of water soluble double-decker phthalocyanine. The thermodynamic parameters for interaction, K, Delta G(0), Delta H-0 and Delta S-0 were calculated between the temperature ranges of 25 degrees C-75 degrees C. To the best of our knowledge, this is the first study about a double-decker phthalocyanine and DNA interaction. (C) 2016 Published by Elsevier B.V. | en_US |
dc.description.sponsorship | Univ Coimbra | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.relation.isversionof | 10.1016/j.saa.2016.01.019 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | ct-DNA | en_US |
dc.subject | Double-decker phthalocyanine | en_US |
dc.subject | Spectroscopic investigation | en_US |
dc.subject | Gel electrophoresis | en_US |
dc.subject | Viscosity | en_US |
dc.title | Analytical approaches for clarification of DNA-double decker phthalocyanine binding mechanism: As an alternative anticancer chemotherapeutic | en_US |
dc.type | article | en_US |
dc.relation.journal | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | en_US |
dc.contributor.department | [Bagda, Esra] Cumhuriyet Univ, Dept Analyt Chem, Fac Pharm, Sivas, Turkey -- [Yabas, Ebru] Cumhuriyet Univ, Dept Chem, Fac Sci, Sivas, Turkey -- [Bagda, Efican] Cumhuriyet Univ, Dept Mol Biol & Genet, Fac Sci, Sivas, Turkey | en_US |
dc.contributor.authorID | Bagda, Efkan -- 0000-0002-3925-3430 | en_US |
dc.identifier.volume | 172 | en_US |
dc.identifier.endpage | 204 | en_US |
dc.identifier.startpage | 199 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |