dc.contributor.author | Ersoy, Gulcin Sahin | |
dc.contributor.author | Ensari, Tugba Altun | |
dc.contributor.author | Vatansever, Dogan | |
dc.contributor.author | Emirdar, Volkan | |
dc.contributor.author | Cevik, Ozge | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:01Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:01Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0951-3590 | |
dc.identifier.issn | 1473-0766 | |
dc.identifier.uri | https://dx.doi.org/10.1080/09513590.2016.1223286 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6854 | |
dc.description | WOS: 000395036200008 | en_US |
dc.description | PubMed ID: 27690684 | en_US |
dc.description.abstract | Objective: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Mullerian hormone (AMH) levels, atherogenic profile and metabolic parametersMethods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle. Serum WISP1, betatrophin, homeostasis model assessment of insulin resistance (HOMA-IR) and AMH levels were evaluated. Univariate and multivariate analyses were performed between betatrophin, WISP1 levels and AMH levels, metabolic and atherogenic parameters.Results: Serum WISP1 and betatrophin values were elevated in the PCOS group than in the control group. Moreover, serum WISP1 and betatrophin levels were higher in the obese PCOS subgroup than in normal weight and obese control subgroups. Multivariate analyses revealed that Body mass index, HOMA-IR, AMH independently and positively predicted WISP1 levels. Serum betatrophin level variability was explained by homocysteine, HOMA-IR and androstenedione levels.Conclusion: WISP1 and betatrophin may play a key role on the pathogenesis of PCOS. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.relation.isversionof | 10.1080/09513590.2016.1223286 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | AMH | en_US |
dc.subject | betatrophin | en_US |
dc.subject | insulin resistance | en_US |
dc.subject | polycystic ovary syndrome | en_US |
dc.subject | WISP1 | en_US |
dc.title | Novel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profile | en_US |
dc.type | article | en_US |
dc.relation.journal | GYNECOLOGICAL ENDOCRINOLOGY | en_US |
dc.contributor.department | [Ersoy, Gulcin Sahin -- Vatansever, Dogan] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Dept Obstet & Gynecol, TR-34852 Istanbul, Turkey -- [Ensari, Tugba Altun] Etlik Zubeyde Hanim Womens Hlth Educ & Res Hosp, Dept Obstet & Gynecol, Ankara, Turkey -- [Emirdar, Volkan] Izmir Univ, Dept Obstet & Gynecol, Izmir, Turkey -- [Cevik, Ozge] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkey | en_US |
dc.contributor.authorID | Cevik, Ozge -- 0000-0002-9325-3757 | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 123 | en_US |
dc.identifier.startpage | 119 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |