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dc.contributor.authorErsoy, Gulcin Sahin
dc.contributor.authorEnsari, Tugba Altun
dc.contributor.authorVatansever, Dogan
dc.contributor.authorEmirdar, Volkan
dc.contributor.authorCevik, Ozge
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:01Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:01Z
dc.date.issued2017
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.urihttps://dx.doi.org/10.1080/09513590.2016.1223286
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6854
dc.descriptionWOS: 000395036200008en_US
dc.descriptionPubMed ID: 27690684en_US
dc.description.abstractObjective: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Mullerian hormone (AMH) levels, atherogenic profile and metabolic parametersMethods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle. Serum WISP1, betatrophin, homeostasis model assessment of insulin resistance (HOMA-IR) and AMH levels were evaluated. Univariate and multivariate analyses were performed between betatrophin, WISP1 levels and AMH levels, metabolic and atherogenic parameters.Results: Serum WISP1 and betatrophin values were elevated in the PCOS group than in the control group. Moreover, serum WISP1 and betatrophin levels were higher in the obese PCOS subgroup than in normal weight and obese control subgroups. Multivariate analyses revealed that Body mass index, HOMA-IR, AMH independently and positively predicted WISP1 levels. Serum betatrophin level variability was explained by homocysteine, HOMA-IR and androstenedione levels.Conclusion: WISP1 and betatrophin may play a key role on the pathogenesis of PCOS.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.isversionof10.1080/09513590.2016.1223286en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAMHen_US
dc.subjectbetatrophinen_US
dc.subjectinsulin resistanceen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectWISP1en_US
dc.titleNovel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profileen_US
dc.typearticleen_US
dc.relation.journalGYNECOLOGICAL ENDOCRINOLOGYen_US
dc.contributor.department[Ersoy, Gulcin Sahin -- Vatansever, Dogan] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Dept Obstet & Gynecol, TR-34852 Istanbul, Turkey -- [Ensari, Tugba Altun] Etlik Zubeyde Hanim Womens Hlth Educ & Res Hosp, Dept Obstet & Gynecol, Ankara, Turkey -- [Emirdar, Volkan] Izmir Univ, Dept Obstet & Gynecol, Izmir, Turkey -- [Cevik, Ozge] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkeyen_US
dc.contributor.authorIDCevik, Ozge -- 0000-0002-9325-3757en_US
dc.identifier.volume33en_US
dc.identifier.issue2en_US
dc.identifier.endpage123en_US
dc.identifier.startpage119en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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