dc.contributor.author | Ersoy, Gulcin Sahin | |
dc.contributor.author | Eken, Meryem Kurek | |
dc.contributor.author | Cevik, Ozge | |
dc.contributor.author | Cilingir, Ozlem T. | |
dc.contributor.author | Tal, Reshef | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:02Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:02Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1472-6483 | |
dc.identifier.issn | 1472-6491 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.rbmo.2016.11.007 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6873 | |
dc.description | WOS: 000393171200001 | en_US |
dc.description | PubMed ID: 27913135 | en_US |
dc.description.abstract | This study evaluated the effect of mycophenolate mofetil (MMF) on uterine tissue preservation following ischaemia/reperfusion (I/R) injury. Uterine I/R injury was induced in rats by clamping the lower abdominal aorta and ovarian arteries for 30 min. Group I/R + V (n = 7) received vehicle alone while Group I/R + M (n = 7) received 20 mg/kg/day MMF. Control groups underwent sham surgery and received vehicle (Group C) or 20 mg/kg/day MMF (Group M) (n = 7 for both). Four hours after detorsion, uterine tissue 8-hydroxy-2'-deoxyguanosine (8-OHdG), glutathione, malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD) and serum ischaemia modified albumin (IMA) concentrations were measured. Histopathological analyses were performed. The I/R + M group showed significant reduction in serum IMA and uterine tissue 8-OHdG, MDA and MPO and significant increase in SOD concentrations compared with the I/R + V group, indicating a protective effect against I/R oxidative damage (P = 0.009, P = 0.006, P = 0.002, P = 0.003 and P = 0.009, respectively). Histopathological evaluation revealed MMF treatment resulted in significantly less tissue and cellular damage and apoptosis compared with the I/R + V group. These results indicate MMF is effective in attenuating uterine tissue damage and preventing apoptosis following uterine I/R injury, probably via anti-inflammatory and anti-oxidative action. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.relation.isversionof | 10.1016/j.rbmo.2016.11.007 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | mycophenolate mofetil | en_US |
dc.subject | oxygen species-free radicals | en_US |
dc.subject | rat | en_US |
dc.subject | uterine ischaemia-reperfusion | en_US |
dc.subject | uterine transplantation | en_US |
dc.title | Mycophenolate mofetil attenuates uterine ischaemia/reperfusion injury in a rat model | en_US |
dc.type | article | en_US |
dc.relation.journal | REPRODUCTIVE BIOMEDICINE ONLINE | en_US |
dc.contributor.department | [Ersoy, Gulcin Sahin] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Eken, Meryem Kurek] Zeynep Kamil Educ & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Cevik, Ozge] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkey -- [Cilingir, Ozlem T.] Marmara Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey -- [Tal, Reshef] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, New Haven, CT USA | en_US |
dc.contributor.authorID | Cilingir Kaya, Ozlem Tugce -- 0000-0002-2591-9174; Cevik, Ozge -- 0000-0002-9325-3757; Tal, Reshef -- 0000-0002-2500-9904; Sahin Ersoy, Gulcin -- 0000-0003-2354-3668 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 123 | en_US |
dc.identifier.startpage | 115 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |