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dc.contributor.authorGorgun, Emine Pirim
dc.contributor.authorToker, Hulya
dc.contributor.authorKorkmaz, Ertan Mahir
dc.contributor.authorPoyraz, Omer
dc.descriptionWOS: 000396564700010en_US
dc.descriptionPubMed ID: 28099578en_US
dc.description.abstractGenetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin (IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene polymorphisms on the clinical outcomes of non-surgical periodontal therapy and cytokine levels in gingival crevicular fluid (GCF) and serum. Fifty-three patients with GAgP and 50 periodontally healthy individuals were included in this study. Clinical parameters, GCF and blood samples were collected at baseline and at 6-week. Non-surgical periodontal therapy was performed in patients with GAgP. Gene analysis were determined by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) and cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA). GAgP patients showed significant improvement on clinical parameters after periodontal therapy (p<0.05). In the GAgP group, IL-6 GG genotype and G allele frequency were higher than in the control group. GCF IL-6 level was also significantly lower at 6-week in the GAgP group. Higher GCF IL-10 levels were observed in patients carrying the IL-6 GG genotype than in those carrying the GC+CC genotype at baseline. In conclusion, IL-6 (-174) and IL-10 (-597) gene polymorphisms were found to be associated with GAgP and genotype distribution did not affect the outcome of non-surgical periodontal therapy, while patients with IL-6 (-174) GG genotype had higher levels of GCF IL-10 levels.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [Dis-113]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Project Fund of Cumhuriyet University under the project number Dis-113.en_US
dc.subjectAggressive Periodontitisen_US
dc.titleIL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parametersen_US
dc.relation.journalBRAZILIAN ORAL RESEARCHen_US
dc.contributor.department[Gorgun, Emine Pirim -- Toker, Hulya] Cumhuriyet Univ, Dept Periodontol, Fac Dent, Sivas, Turkey -- [Korkmaz, Ertan Mahir] Cumhuriyet Univ, Dept Mol Biol & Genet, Fac Sci, Sivas, Turkey -- [Poyraz, Omer] Cumhuriyet Univ, Dept Microbiol, Fac Med, Sivas, Turkeyen_US
dc.contributor.authorIDKorkmaz, Ertan Mahir -- 0000-0003-0699-1354en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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