dc.contributor.author | Gorgun, Emine Pirim | |
dc.contributor.author | Toker, Hulya | |
dc.contributor.author | Korkmaz, Ertan Mahir | |
dc.contributor.author | Poyraz, Omer | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:03Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:03Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1807-3107 | |
dc.identifier.uri | https://dx.doi.org/10.1590/1807-3107BOR-2017.vol31.0012 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6883 | |
dc.description | WOS: 000396564700010 | en_US |
dc.description | PubMed ID: 28099578 | en_US |
dc.description.abstract | Genetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin (IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene polymorphisms on the clinical outcomes of non-surgical periodontal therapy and cytokine levels in gingival crevicular fluid (GCF) and serum. Fifty-three patients with GAgP and 50 periodontally healthy individuals were included in this study. Clinical parameters, GCF and blood samples were collected at baseline and at 6-week. Non-surgical periodontal therapy was performed in patients with GAgP. Gene analysis were determined by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) and cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA). GAgP patients showed significant improvement on clinical parameters after periodontal therapy (p<0.05). In the GAgP group, IL-6 GG genotype and G allele frequency were higher than in the control group. GCF IL-6 level was also significantly lower at 6-week in the GAgP group. Higher GCF IL-10 levels were observed in patients carrying the IL-6 GG genotype than in those carrying the GC+CC genotype at baseline. In conclusion, IL-6 (-174) and IL-10 (-597) gene polymorphisms were found to be associated with GAgP and genotype distribution did not affect the outcome of non-surgical periodontal therapy, while patients with IL-6 (-174) GG genotype had higher levels of GCF IL-10 levels. | en_US |
dc.description.sponsorship | Scientific Research Project Fund of Cumhuriyet University [Dis-113] | en_US |
dc.description.sponsorship | This study was supported by the Scientific Research Project Fund of Cumhuriyet University under the project number Dis-113. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA | en_US |
dc.relation.isversionof | 10.1590/1807-3107BOR-2017.vol31.0012 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Interleukin-6 | en_US |
dc.subject | Interleukin-10 | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Genetic | en_US |
dc.subject | Aggressive Periodontitis | en_US |
dc.title | IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters | en_US |
dc.type | article | en_US |
dc.relation.journal | BRAZILIAN ORAL RESEARCH | en_US |
dc.contributor.department | [Gorgun, Emine Pirim -- Toker, Hulya] Cumhuriyet Univ, Dept Periodontol, Fac Dent, Sivas, Turkey -- [Korkmaz, Ertan Mahir] Cumhuriyet Univ, Dept Mol Biol & Genet, Fac Sci, Sivas, Turkey -- [Poyraz, Omer] Cumhuriyet Univ, Dept Microbiol, Fac Med, Sivas, Turkey | en_US |
dc.contributor.authorID | Korkmaz, Ertan Mahir -- 0000-0003-0699-1354 | en_US |
dc.identifier.volume | 31 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |