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dc.contributor.authorOzbilum, N.
dc.contributor.authorArslan, S.
dc.contributor.authorYanartas, M.
dc.contributor.authorYilmaz, Z.
dc.contributor.authorBerkan, O.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:04Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:04Z
dc.date.issued2017
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6890
dc.descriptionWOS: 000450272100014en_US
dc.description.abstractObjective: Coronary artery disease, the leading cause of morbidity and mortality worldwide, is an inflammatory disease. The X-ray repair cross complementing 1 (XRCC1) gene plays the role of scaffolding protein for the base excision repair (BER) and single strand break (SSB) repair. Methods: The study population consisted of 402 participants living in the same region and classified into case group (n = 201) and control group (n = 201). Phenol-chloroform method was used to extract DNA from blood samples of the study participants. The X-ray repair cross complementing 1 genotypes were determined using polymerase chain reaction-restriction/ fragment length polymorphism (PCR/RFLP) methods. Results: No statistically significant difference was found between the study groups in terms of allele and genotype frequencies in XRCC1 Arg194Trp polymorphism. However, distribution of XRCC1 399Gln allele frequency was found to differ at a statistically significant level between the case and the control groups (p = 0.003; OR = 1.56). Regarding the Arg/Arg genotype in Arg399Gln polymorphism, a statistically significant difference was detected in the distribution of Gln/Gln genotype (p = 0.017; adj OR = 3.11). Statistically significant differences were also recorded for Arg399Gln polymorphism among the smoking male participants with hypertension (p = 0.009;p = 0.031;p = 0.032, respectively). Conclusion: The study suggests that XRCC1 399Gln/Gln genotype may be a significant risk factor for coronary artery disease.en_US
dc.description.sponsorshipResearch Council of Cumhuriyet University (CUBAP) [F-340]en_US
dc.description.sponsorshipThis study was supported by the Research Council of Cumhuriyet University (CUBAP, Project No: F-340).en_US
dc.language.isoengen_US
dc.publisherUNIV WEST INDIES FACULTY MEDICAL SCIENCESen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectgenetic polymorphismen_US
dc.subjectXRCC1en_US
dc.titleArg399Gln Polymorphism of the XRCC1 Gene is Associated with Coronary Artery Disease in a Turkish Populationen_US
dc.typearticleen_US
dc.relation.journalWEST INDIAN MEDICAL JOURNALen_US
dc.contributor.department[Ozbilum, N.] Cumhuriyet Univ, Fac Sci, Dept Mol Biol & Genet, Sivas, Turkey -- [Arslan, S.] Cumhuriyet Univ, Fac Med, Dept Med Biol, TR-58140 Sivas, Turkey -- [Yanartas, M.] Kartal Kosuyolu Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkey -- [Yilmaz, Z.] Gebze Inst Technol, Fac Sci, Dept Mol Biol & Genet, Kocaeli, Turkey -- [Berkan, O.] Cumhuriyet Univ, Dept Cardiovasc Surg, Sch Med, Sivas, Turkeyen_US
dc.identifier.volume66en_US
dc.identifier.issue6en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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