dc.contributor.author | Yucel, Birsen | |
dc.contributor.author | Hayta, Sibel Berksoy | |
dc.contributor.author | Goze, Omer Fahrettin | |
dc.contributor.author | Erdis, Eda | |
dc.contributor.author | Bahar, Seher | |
dc.contributor.author | Celasun, Mustafa Gurol | |
dc.contributor.author | Kacan, Turgut | |
dc.contributor.author | Akyol, Melih | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:04Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:04Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1019-214X | |
dc.identifier.issn | 1308-6294 | |
dc.identifier.uri | https://dx.doi.org/10.4274/turkderm.74150 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6895 | |
dc.description | WOS: 000435795800001 | en_US |
dc.description.abstract | Background and Design: This study aimed to investigate whether 5% strontium (Sr) chloride hexahydrate has preventive or therapeutic effects on the radiotherapy (RT)-induced adverse skin effects. Materials and Methods: Sixty-four female Wistar albino rats weighing 200-210 g, aged 4.5-5 months were divided into eight groups. Results: There were significant differences between control group and the other groups according to the Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria (RTOG) and histopathological findings (p<0.050). However, there were no significant differences between RT group and treatment groups (p>0.05). In addition, there were no significant differences among treatment groups (p>0.05). Statistical results were as follows according to the immunohistochemical evaluation of transforming growth factor-beta: group 1 and 4 (p=0.015), group 1 and 5 (p=0.014), group 1 and 6 (p=0.035), group 1 and 8 (p=0.046), group 2 and 6 (p-0.047), group 4 and 6 (p=0.031); and according to the immunohistochemical evaluation of tumor necrosis factor-alpha: group 1 and 2 (p=0.024), group 1 and 8 (p=0.045). Conclusion: Topical treatment with Sr at a concentration of 5% is insufficient to prevent the side effects of RT involving the skin, as assessed by the RTOG scoring, histopathological findings, and immunological markers. | en_US |
dc.description.sponsorship | Coordination Department of Scientific Research Projects of Cumhuriyet University [T607] | en_US |
dc.description.sponsorship | This study was supported by Coordination Department of Scientific Research Projects of Cumhuriyet University. Project number: T607. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TURKISH SOC DERMATOLOGY VENEROLOGY | en_US |
dc.relation.isversionof | 10.4274/turkderm.74150 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Strontium | en_US |
dc.subject | dermatitis | en_US |
dc.subject | radiation | en_US |
dc.subject | skin toxicity | en_US |
dc.title | Therapeutic and prophylactic effects of strontium on radiotherapy-induced skin toxicity in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY | en_US |
dc.contributor.department | [Yucel, Birsen -- Erdis, Eda -- Bahar, Seher -- Celasun, Mustafa Gurol] Cumhuriyet Univ, Fac Med, Dept Radiat Oncol, Sivas, Turkey -- [Hayta, Sibel Berksoy -- Akyol, Melih] Cumhuriyet Univ, Fac Med, Dept Dermatol, Sivas, Turkey -- [Goze, Omer Fahrettin] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Kacan, Turgut] Afyonkarahisar State Hosp, Clin Med Oncol, Afyon, Turkey | en_US |
dc.identifier.volume | 51 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 114 | en_US |
dc.identifier.startpage | 109 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |