dc.contributor.author | Karakus, Savas | |
dc.contributor.author | Bagci, Binnur | |
dc.contributor.author | Bagci, Gokhan | |
dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Yildiz, Caglar | |
dc.contributor.author | Akkar, Ozlem | |
dc.contributor.author | Cetin, Ali | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:18Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:18Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1064-1955 | |
dc.identifier.issn | 1525-6065 | |
dc.identifier.uri | https://dx.doi.org/10.1080/10641955.2016.1250904 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7013 | |
dc.description | WOS: 000403435800002 | en_US |
dc.description | PubMed ID: 28001450 | en_US |
dc.description.abstract | Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE).Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level.Results: For SDF-1 3A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0.04, 0.023, and 0.029, respectively). For CXCR4 SNP, the frequency of CT genotype, total number of CT and TT genotypes, and the T allele frequency were higher in PE patients than controls (p = 0.04, 0.006, and 0.005, respectively). SDF-1 serum level was detected higher in preeclamptic women compared with controls (p = 0.001). In PE patients, there was no significant association between serum SDF-1 levels and genotypes of SDF-1 3A SNP. SDF-1 level was significantly higher in patients bearing CXCR4 CT genotype than CC genotype (p = 0.001). Furthermore, SDF-1 levels in patients bearing CT+TT genotype were found higher than that of patients with CC genotypes (p = 0.001).Conclusion: Results of our study suggest that SDF-1 3A and CXCR4 polymorphisms and elevated serum SDF-1 levels may have a role in the development of PE. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS INC | en_US |
dc.relation.isversionof | 10.1080/10641955.2016.1250904 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | CXCL12 gene | en_US |
dc.subject | CXCR4 gene | en_US |
dc.subject | SDF-1 | en_US |
dc.subject | polymorphism | en_US |
dc.subject | preeclampsia | en_US |
dc.title | SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia | en_US |
dc.type | article | en_US |
dc.relation.journal | HYPERTENSION IN PREGNANCY | en_US |
dc.contributor.department | [Karakus, Savas -- Yildiz, Caglar -- Akkar, Ozlem -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, Sivas, Turkey -- [Bagci, Gokhan] Cumhuriyet Univ, Sch Med, Dept Med Genet, Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 130 | en_US |
dc.identifier.startpage | 124 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |