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Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

Date

2016

Author

Ergonul, O.
Aydin, M.
Azap, A.
Basaran, S.
Tekin, S.
Kaya, S.
Gulsun, S.
Yoruk, G.
Kursun, E.
Yesilkaya, A.
Simsek, F.
Yilmaz, E.
Bilgin, H.
Hatipoglu, C.
Cabadak, H.
Tezer, Y.
Togan, T.
Karaoglan, I.
Inan, A.
Engin, A.
Aliskan, H. E.
Yavuz, S. S.
Erdinc, S.
Mulazimoglu, L.
Azap, O.
Can, F.
Akalin, H.
Timurkaynak, F.

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Abstract

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Source

JOURNAL OF HOSPITAL INFECTION

Volume

94

Issue

4

URI

https://dx.doi.org/10.1016/j.jhin.2016.08.012
https://hdl.handle.net/20.500.12418/7093

Collections

  • Makale Koleksiyonu [5200]
  • Makale Koleksiyonu [5745]
  • Öksüz Yayınlar Koleksiyonu - WoS [6175]



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