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dc.contributor.authorDemirpence, Ozlem
dc.contributor.authorDogan, Halef Okan
dc.contributor.authorErsan, Serpil
dc.contributor.authorSahin, Mehtap
dc.contributor.authorSahin, Hasan
dc.contributor.authorBakir, Mehmet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:35Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:35Z
dc.date.issued2016
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.urihttps://dx.doi.org/10.7883/yoken.JJID.2015.392
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7114
dc.descriptionWOS: 000389285500009en_US
dc.descriptionPubMed ID: 27000451en_US
dc.description.abstractLevels of presepsin (a soluble cluster of differentiation subtype 14 [CD14]) are thought to increase in cases of bacterial infection. CD14 has also been found to play a role in the pathogenesis of various viral diseases. Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arboviral infection. Our study focuses on presepsin levels as a biomarker for CCHF. Serum presepsin levels in a CCHF group (n = 59) and control group (n = 28) were compared. Patients with CCHF were classified according to severity grading score as having mild, moderate, or severe infection and were allocated to corresponding subgroups (groups 1, 2, and 3, respectively). Presepsin levels were measured in serum samples by using a commercial enzyme-linked immunosorbent assay kit. The mean presepsin levels in the CCHF group as a whole and the healthy group were found to be significantly different (1,499.46 +/- 411.96 pg/ml and 430.68 +/- 61.21 pg/ml, respectively). The mean presepsin levels of the CCHF subgroups (1, 2 and 3) and the healthy group were also found to be significantly different (1,204.53 +/- 371.18, 1,464.21 +/- 338.37, 2,007.36 +/- 82.18, and 430.68 +/- 61.21 pg/ml, respectively) (p < 0.05). We also found that as the severity of the disease increased, the presepsin level also increased. We postulate that the presepsin levels could be used as a supportive biomarker for diagnosis and follow-up of the disease.en_US
dc.language.isoengen_US
dc.publisherNATL INST INFECTIOUS DISEASESen_US
dc.relation.isversionof10.7883/yoken.JJID.2015.392en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePresepsin Levels of Patients with Crimean-Congo Hemorrhagic Feveren_US
dc.typearticleen_US
dc.relation.journalJAPANESE JOURNAL OF INFECTIOUS DISEASESen_US
dc.contributor.department[Demirpence, Ozlem -- Dogan, Halef Okan -- Ersan, Serpil -- Sahin, Mehtap] Cumhuriyet Univ, Dept Biochem, Fac Med, TR-58140 Sivas, Turkey -- [Bakir, Mehmet] Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Sahin, Hasan] Publ Hlth Lab, Malatya, Turkeyen_US
dc.identifier.volume69en_US
dc.identifier.issue6en_US
dc.identifier.endpage509en_US
dc.identifier.startpage505en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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