Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper
Tarih
2016Yazar
Farmakis, DimitriosAlvarez, Julian
Ben Gal, Tuvia
Brito, Dulce
Fedele, Francesco
Fonseca, Candida
Gordon, Anthony C.
Gotsman, Israel
Grossini, Elena
Guarracino, Fabio
Harjola, Veli-Pekka
Hellman, Yaron
Heunks, Leo
Ivancan, Visnja
Karavidas, Apostolos
Kivikko, Matti
Lomivorotov, Vladimir
Longrois, Dan
Masip, Josep
Metra, Marco
Morelli, Andrea
Nikolaou, Maria
Papp, Zoltan
Parkhomenko, Alexander
Poelzl, Gerhard
Pollesello, Piero
Ravn, Hanne Berg
Rex, Steffen
Riha, Hynek
Ricksten, Sven-Erik
Schwinger, Robert H. G.
Vrtovec, Bojan
Yilmaz, M. Birhan
Zielinska, Marzenna
Parissis, John
Üst veri
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Levosimendan is a positive inotrope with vasodilating properties (inodilator) indicated for decompensated heart failure (HF) patients with low cardiac output. Accumulated evidence supports several pleiotropic effects of levosimendan beyond inotropy, the heart and decompensated HF. Those effects are not readily explained by cardiac function enhancement and seem to be related to additional properties of the drug such as anti-inflammatory, anti-oxidative and anti-apoptotic ones. Mechanistic and proof-of-concept studies are still required to clarify the underlying mechanisms involved, while properly designed clinical trials are warranted to translate preclinical or early-phase clinical data into more robust clinical evidence. The present position paper, derived by a panel of 35 experts in the field of cardiology, cardiac anesthesiology, intensive care medicine, cardiac physiology, and cardiovascular pharmacology from 22 European countries, compiles the existing evidence on the pleiotropic effects of levosimendan, identifies potential novel areas of clinical application and defines the corresponding gaps in evidence and the required research efforts to address those gaps. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
Kaynak
INTERNATIONAL JOURNAL OF CARDIOLOGYCilt
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