dc.contributor.author | Hasbek, Zekiye | |
dc.contributor.author | Dogan, Omer Tamer | |
dc.contributor.author | San, Ismail | |
dc.contributor.author | Yucel, Birsen | |
dc.contributor.author | Seker, Mehmet Metin | |
dc.contributor.author | Turgut, Bulent | |
dc.contributor.author | Berk, Serdar | |
dc.contributor.author | Silig, Yavuz | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:40Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:40Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2146-1414 | |
dc.identifier.issn | 2147-1959 | |
dc.identifier.uri | https://dx.doi.org/10.4274/mirt.97269 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7136 | |
dc.description | WOS: 000391387000001 | en_US |
dc.description | PubMed ID: 27751972 | en_US |
dc.description.abstract | Objective: Mutations in the p53 gene are the most commonly observed genetic abnormalities in malignancies. The purpose of this study was to assess the diagnostic value of serum anti-p53 antibody (Ab) along with the correlation between serum anti-p53 Ab level and quantitative positron emission tomography (PET) parameters such as maximum standardized uptake value (SUVmax), SUVave, metabolic tumor volume, total lesion glycolysis (TLG) and tumor size. Methods: Serum anti-p53 Ab level was studied in three groups. Patients who underwent F-18-fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging for staging of previously diagnosed lung cancer constituted the first group, while patients who underwent F-18-FDG PET/CT imaging for evaluation of suspicious pulmonary nodules detected on thorax CT and did not show pathologic FDG accumulation (NAPN= pulmonary nodule with non avid-FDG) were enrolled in the second group. The third group consisted of healthy volunteers. Results: Twenty-eight patients with lung cancer (median age: 62.5, range: 39-77years), 28 patients with NAPN (median age: 65, range: 33-79 years), and 24 healthy volunteers (median age: 62, range: 44-74 years) were enrolled in the study. The serum anti-p53 Ab level was low in healthy volunteers while it was higher in both lung cancer patients and NAPN patients (p< 0.05). When serum anti-p53 Ab level and PET parameters were evaluated, there was no significant correlation between serum anti-p53 Ab level and SUVmax, SUVave, TLG, tumor volume and tumor size of patients with lung cancer (p> 0.05). Besides, there was no significant difference between serum anti-p53 Ab level and lesion size of NAPN patients (p> 0.05). Conclusion: It was determined that serum anti-p53 Ab levels are not significantly correlated with PET parameters, and that serum anti-p53 Ab levels increase in any benign or malignant lung parenchyma pathology as compared to healthy volunteers. These results indicate that this Ab cannot be used as a predictor of malignancy in a lung lesion. | en_US |
dc.description.sponsorship | Cumhuriyet University Scientific Research Project Unit [T-597] | en_US |
dc.description.sponsorship | The work was supported by grants from Cumhuriyet University Scientific Research Project Unit (T-597). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | GALENOS YAYINCILIK | en_US |
dc.relation.isversionof | 10.4274/mirt.97269 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Anti-p53 antibody | en_US |
dc.subject | lung cancer | en_US |
dc.subject | fluorodeoxyglucose | en_US |
dc.subject | positron emission tomography/computed tomography | en_US |
dc.title | The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | MOLECULAR IMAGING AND RADIONUCLIDE THERAPY | en_US |
dc.contributor.department | [Hasbek, Zekiye -- Turgut, Bulent] Cumhuriyet Univ, Fac Med, Dept Nucl Med, Sivas, Turkey -- [Dogan, Omer Tamer -- Berk, Serdar] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey -- [San, Ismail -- Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Biochem, Sivas, Turkey -- [Yucel, Birsen] Cumhuriyet Univ, Fac Med, Dept Radiat Oncol, Sivas, Turkey -- [Seker, Mehmet Metin] Turgut Ozal Univ, Fac Med, Dept Med Oncol, Ankara, Turkey | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 113 | en_US |
dc.identifier.startpage | 107 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |