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dc.contributor.authorDastan, Taner
dc.contributor.authorDastan, Sevgi Durna
dc.contributor.authorAtas, Mehmet
dc.contributor.authorOrek, Cahit
dc.contributor.authorKoparir, Pelin
dc.contributor.authorParlak, Akif Evren
dc.contributor.authorBaral, Inanc
dc.contributor.authorKoparir, Metin
dc.contributor.authorCetin, Ahmet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:49Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:49Z
dc.date.issued2016
dc.identifier.issn1011-601X
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7184
dc.descriptionWOS: 000389622900021en_US
dc.descriptionPubMed ID: 28476714en_US
dc.description.abstractAminophosphinic acids which are organophosphorus compounds widely investigated for potential production of antibacterial, antitumor and antiviral materials. In vitro antioxidant, cytotoxic and antimicrobial activities of synthesized novel compounds of 8 different bis(a-amino alkyl)phosphinic acids (4a-h) were investigated on MCF-7 breast adenocarcinoma cell and human umbilical vein endothelial cell (HUVEC) cultures. Malondialdehyde (MDA) levels were evaluated as an indication of lipid peroxidation in cell cultures for antioxidant capacities. In vitro antioxidant activities in cell cultures were determined by evaluating totals of antioxidant, oxidant, thiol levels and activities of paraoxanase, aryl esterase. It was found that 4c compound reduced MDA level significantly while 4a and 4g compounds increased MDA levels significantly compared to control. 4c compound was found most effective in reducing MDA levels by neutralizing reactive oxygen species to prevent cell damage while compounds 4c, 4f and 4h were found presenting adequate activity with other antioxidants. In vitro anti-proliferation was evaluated on MCF-7 and HUVEC cells using XTT to investigate anti-cancer potentials as therapeutics. Compounds 4c, 4e and 4f were exhibited better compared to others. Most compounds were found cytotoxic to both MCF-7 and HUVECs. Antimicrobial and antifungal activities were investigated by disc diffusion and compared to MICs of Gentamycin and Nystatin.en_US
dc.language.isoengen_US
dc.publisherUNIV KARACHIen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanticanceren_US
dc.subjectantimicrobialen_US
dc.subjectbis phosphinic acidsen_US
dc.subjectcytotoxicityen_US
dc.subjectoxidative stressen_US
dc.titleInvestigation of anti-proliferative and antioxidative effects of some bis (alpha-amino) phosphinic acid derivativesen_US
dc.typearticleen_US
dc.relation.journalPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCESen_US
dc.contributor.department[Dastan, Taner -- Cetin, Ahmet] Bingol Univ, Fac Arts & Sci, Dept Chem, Div Organ Chem, Bingol, Turkey -- [Dastan, Sevgi Durna -- Baral, Inanc] Cumhuriyet Univ, Div Biometry & Genet, Dept Zootech & Anim Nutr, Fac Vet Med, Sivas, Turkey -- [Atas, Mehmet] Cumhuriyet Univ, Div Pharmaceut Microbiol, Dept Basic Pharmaceut Sci, Fac Pharm, Sivas, Turkey -- [Orek, Cahit -- Koparir, Metin] Firat Univ, Fac Arts & Sci, Dept Chem, Elazig, Turkey -- [Orek, Cahit -- Koparir, Pelin -- Koparir, Metin] Inst Forens, Dept Chem, Malatya, Turkey -- [Parlak, Akif Evren] Firat Univ, Keban Vocat Sch Higher Educ, Environm Protect & Control Program, Elazig, Turkeyen_US
dc.contributor.authorIDParlak, Akif Evren -- 0000-0002-2579-9985; orek, cahit -- 0000-0002-3854-1537en_US
dc.identifier.volume29en_US
dc.identifier.issue5en_US
dc.identifier.endpage1862en_US
dc.identifier.startpage1853en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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