dc.contributor.author | Yuce, Salim | |
dc.contributor.author | Bagci, Binnur | |
dc.contributor.author | Bagci, Gokhan | |
dc.contributor.author | Dogan, Mansur | |
dc.contributor.author | Koc, Sema | |
dc.contributor.author | Sezgin, Ilhan | |
dc.contributor.author | Candan, Ferhan | |
dc.contributor.author | Uysal, Ismail Onder | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:56Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:56Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1309-0720 | |
dc.identifier.issn | 1309-2014 | |
dc.identifier.uri | https://dx.doi.org/10.4328/JCAM.4523 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7216 | |
dc.description | WOS: 000410618200028 | en_US |
dc.description.abstract | Aim: Recurrent aphthous stomatitis (RAS) is one of the most frequent diseases of the oral mucosa, characterized by chronic, painful, recurrent, and necrotizing ulcerations. The precise etiology and pathogenesis of RAS have not been clarified. Therefore. we aimed to investigate serum levels of VEGF. sVEGFR-1, and endostatin as well as the frequencies of VEGF +936 C/T and -1154 C/A single nucleotide polymorphisms (SNPs) in Turkish patients with recurrent aphthous stomatitis. Material and Method: Forty-two patients with RAS (24 minor RAS and 18 major RAS) and 37 healthy subjects were included in the study. Serum levels of VEGF, sVEC FR-1, and endostatin were measured using the ELISA method. VEGF +936 C/T and-1154 C/A SNPs were determined by the PCR-RFLP method. Results: The mean serum level of VEGF was found higher in bearing CC genotype of +936 CFI SNP compared with CT genotype (639.5 +/- 309.1 vs 442.1 +/- 197.8: p = 0.032). VEGF-1154 GA genotype was found to be more frequent in patients with minor RAS and GG genotype was more frequent in patients with major RAS (p = 0.022). There was a significant difference between minor RAS and major RAS with regard to mean VEGF serum levels (677.1 +/- 316.7 vs 492.9 +/- 242.7; p = 0.032). Discussion: The T allele of +936 C/T SNP is associated with decreased serum VEGF level, and this decrease may have a contributory role in impaired neovascularization and re-epithelialization in the etiology and pathogenesis of RAS. Further studies are needed to determine the role of VEGF in RAS susceptibility and its clinical manifestations. | en_US |
dc.description.sponsorship | Scientific Research Project Fund of Cumhuriyet University (CUBAP) [T-513] | en_US |
dc.description.sponsorship | This work was supported by the Scientific Research Project Fund of Cumhuriyet University (CUBAP) under the project number T-513. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | DERMAN MEDICAL PUBL | en_US |
dc.relation.isversionof | 10.4328/JCAM.4523 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Recurrent Aphthous Stomatitis | en_US |
dc.subject | VEGF | en_US |
dc.subject | VEGFR-1 | en_US |
dc.subject | Endostatin | en_US |
dc.subject | Polymorphism | en_US |
dc.title | VEGF, sVEGFR-1 and Endostatin Serum Levels and VEGF Polymorphisms in Recurrent Aphthous Stomatitis | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE | en_US |
dc.contributor.department | [Yuce, Salim -- Dogan, Mansur -- Uysal, Ismail Onder] Cumhuriyet Univ, Fac Med, Dept Otorhinolaryngol, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-58140 Sivas, Turkey -- [Bagci, Gokhan -- Sezgin, Ilhan] Cumhuriyet Univ, Fac Med, Dept Med Genet, Sivas, Turkey -- [Koc, Sema] Antalya Training & Res Hosp, Dept Otorhinolaryngol, Antalya, Turkey -- [Candan, Ferhan] Cumhuriyet Univ, Fac Med, Dept Internal Med, Sivas, Turkey | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 705 | en_US |
dc.identifier.startpage | 701 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |