Hydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: Results of Haydarpasa-III study
dc.contributor.author | Cag, Yasemin | |
dc.contributor.author | Ozturk-Engin, Derya | |
dc.contributor.author | Gencer, Serap | |
dc.contributor.author | Hasbun, Rodrigo | |
dc.contributor.author | Sengoz, Gonul | |
dc.contributor.author | Crisan, Alexandru | |
dc.contributor.author | Ceran, Nurgul | |
dc.contributor.author | Savic, Branislava | |
dc.contributor.author | Yasar, Kadriye | |
dc.contributor.author | Pehlivanoglu, Filiz | |
dc.contributor.author | Kilicoglu, Gamze | |
dc.contributor.author | Tireli, Hulya | |
dc.contributor.author | Inal, Ayse S. | |
dc.contributor.author | Civljak, Rok | |
dc.contributor.author | Tekin, Recep | |
dc.contributor.author | Elaldi, Nazif | |
dc.contributor.author | Ulu-Kilic, Aysegul | |
dc.contributor.author | Ozguler, Muge | |
dc.contributor.author | Namiduru, Mustafa | |
dc.contributor.author | Sunbul, Mustafa | |
dc.contributor.author | Sipahi, Oguz R. | |
dc.contributor.author | Dulovic, Olga | |
dc.contributor.author | Alabay, Selma | |
dc.contributor.author | Akbulut, Ayhan | |
dc.contributor.author | Sener, Alper | |
dc.contributor.author | Lakatos, Botond | |
dc.contributor.author | Andre, Katell | |
dc.contributor.author | Yemisen, Mucahit | |
dc.contributor.author | Oncu, Serkan | |
dc.contributor.author | Nechifor, Mihai | |
dc.contributor.author | Deveci, Ozcan | |
dc.contributor.author | Senbayrak, Seniha | |
dc.contributor.author | Inan, Asuman | |
dc.contributor.author | Dragovac, Gorana | |
dc.contributor.author | Gul, Hanefi C. | |
dc.contributor.author | Mert, Gurkan | |
dc.contributor.author | Oncul, Oral | |
dc.contributor.author | Kandemir, Bahar | |
dc.contributor.author | Erol, Serpil | |
dc.contributor.author | Agalar, Canan | |
dc.contributor.author | Erdem, Hakan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:44:57Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:44:57Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0028-3886 | |
dc.identifier.issn | 1998-4022 | |
dc.identifier.uri | https://dx.doi.org/10.4103/0028-3886.190258 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7218 | |
dc.description | WOS: 000384527500014 | en_US |
dc.description | PubMed ID: 27625226 | en_US |
dc.description.abstract | Aims: There is no report on the factors affecting the resolution of symptoms related to meningitis during treatment of tuberculous meningitis (TBM). Thus, we examined the factors associated with early therapeutic responses. Materials and Methods: This multicenter study included 507 patients with microbiologically confirmed TBM. However, 94 patients eligible for the analysis were included in this study from 24 centers. Six out of 94 patients died and the statistical analysis was performed with 88 survivors. Early and late responder groups were compared in the statistical analysis. P < 0.05 were considered to show a significant difference. Results: In the multivariate analysis, the presence of vasculitis (P = 0.029, OR = 10.491 [95% CI, 1.27u86.83]) was found to be significantly associated with a delayed fever response whereas hydrocephalus was associated with altered mental status for 9 days duration (P = 0.005, OR = 5.740 [95% CI, 1.68u19.57]). According to linear regression analysis, fever was significantly persisting (7 days) in the presence of vasculitis (17.5 vs. 7, P< 0.001) and hydrocephalus (11 vs. 7, P = 0.029). Hydrocephalus was significantly associated with persisting headache (21 vs. 12, P = 0.025), delayed recovery of consciousness (19.5 vs. 7, P = 0.001), and a delay in complete recovery (21 vs. 14, P = 0.007) in the linear regression analysis. Following institution of treatment, the complaints seemed to disappear in up to 2 weeks among TBM survivors. Conclusions: In the absence of hydrocephalus or vasculitis, one week of anti-tuberculosis treatment seems to be adequate for the resolution of TBM symptoms. Hydrocephalus and vasculitis delay the resolution of TBM symptoms in response to antimycobacterial treatment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MEDKNOW PUBLICATIONS & MEDIA PVT LTD | en_US |
dc.relation.isversionof | 10.4103/0028-3886.190258 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Clinical | en_US |
dc.subject | meningitis | en_US |
dc.subject | response | en_US |
dc.subject | tuberculosis | en_US |
dc.title | Hydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: Results of Haydarpasa-III study | en_US |
dc.type | article | en_US |
dc.relation.journal | NEUROLOGY INDIA | en_US |
dc.contributor.department | [Cag, Yasemin] Istanbul Medeniyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ozturk-Engin, Derya -- Ceran, Nurgul -- Kilicoglu, Gamze -- Tireli, Hulya -- Senbayrak, Seniha -- Inan, Asuman -- Erol, Serpil] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Gencer, Serap] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Hasbun, Rodrigo] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Infect Dis, Houston, TX 77030 USA -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Crisan, Alexandru] Victor Babes Univ Med & Pharm, Dept Infect Dis, Timisoara, Romania -- [Savic, Branislava] Univ Belgrade, Inst Microbiol & Immunol, Natl Reference Lab TB, Fac Med, Belgrade, Serbia -- [Yasar, Kadriye] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Inal, Ayse S.] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Civljak, Rok] Univ Zagreb, Sch Med, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Zagreb, Croatia -- [Tekin, Recep -- Deveci, Ozcan] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Ulu-Kilic, Aysegul -- Alabay, Selma] Erciyes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Ozguler, Muge -- Akbulut, Ayhan] Firat Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Namiduru, Mustafa] Gaziantep Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Sunbul, Mustafa] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sipahi, Oguz R.] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Dulovic, Olga] Clin Ctr Serbia, Clin Infect & Trop Dis, Belgrade, Serbia -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Lakatos, Botond] St Laszlo Hosp, Dept Infect Dis, Budapest, Hungary -- [Andre, Katell] Dax Hosp, Dept Infect Dis, Dax, France -- [Yemisen, Mucahit] Istanbul Univ, Cerrahpasa Med Sch, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Oncu, Serkan] Adnan Menderes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey -- [Nechifor, Mihai] Gr T Popa Univ Med & Pharm, Dept Infect Dis, Iasi, Romania -- [Dragovac, Gorana] Univ Novi Sad, IPH Vojvodina, Fac Med, Dept Prevent & Control Dis, Novi Sad, Serbia -- [Gul, Hanefi C. -- Mert, Gurkan -- Erdem, Hakan] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Oncul, Oral] Istanbul Univ, Dept Infect Dis & Clin Microbiol, Istanbul Fac Med, Istanbul, Turkey -- [Kandemir, Bahar] Necmettin Erbakan Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Agalar, Canan] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey | en_US |
dc.contributor.authorID | Inal, Ayse Seza -- 0000-0002-1182-7164; Gencer, Serap -- 0000-0002-3217-6305; GENCER, SERAP -- 0000-0002-3217-6305; Civljak, Rok -- 0000-0001-8766-7438; Kart Yasar, Kadriye -- 0000-0003-2963-4894 | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 905 | en_US |
dc.identifier.startpage | 896 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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