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dc.contributor.authorCakmak, Erol
dc.contributor.authorYonem, Ozlem
dc.contributor.authorSarac, Bulent
dc.contributor.authorParlak, Mesut
dc.contributor.authorCelik, Cumali
dc.contributor.authorAtaseven, Hilmi
dc.contributor.authorBagcivan, Ihsan
dc.description30th Turkish Gastroenterology Week -- SEP 11-15, 2013 -- Antalya, TURKEYen_US
dc.descriptionWOS: 000383206400013en_US
dc.descriptionPubMed ID: 27606143en_US
dc.description.abstractBackground: Relaxing the sphincter of Oddi (SO) is an important process during endoscopic retrograde cholangiopancreatography (ERCP) procedures. This issue suggests that the easier the sphincterotomy and cannulation, the more post-ERCP complications decrease. Aims: To compare the relaxant effects of ataciguat (a novel soluble guanylyl cyclase activator) and zaprinast (an inhibitor of phosphodiesterase 5) on sheep SO in vitro, thus testing whether they can be used during ERCP. Study Design: Animal experimentation. Methods: Sheep SO rings were placed in tissue baths and their isometric tension to ataciguat and zaprinast were tested. We also tested their isometric tension against ataciguat in the presence of 1H-(1,2,4) oxadiazole (4,3-alpha) quinoxalin-1-one (ODQ) which is a soluble guanylyl cyclase inhibitor. Results: Ataciguat and zaprinast both triggered concentration addicted relaxation on sheep SO rings (p=0.0018, p=0.0025 respectively) but the relaxation of the ataciguat was significantly greater than that of zaprinast at all concentrations (p=0.0024). It was observed that decreased relaxation responses were initiated by ataciguat in the presence of ODQ (p=0.0012). Conclusion: Ataciguat and zaprinast both have relaxing effects on sphincter of Oddi, although that of zaprinast is lower. We believe that ataciguat and zaprinast can be used in ERCP procedures in order to relax the sphincter of Oddi and thus can be used locally in order to decrease complications.en_US
dc.subjectOddi's sphincteren_US
dc.titleComparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddien_US
dc.relation.journalBALKAN MEDICAL JOURNALen_US
dc.contributor.department[Cakmak, Erol -- Yonem, Ozlem] Cumhuriyet Univ, Sch Med, Dept Gastroenterol, Sivas, Turkey -- [Sarac, Bulent -- Bagcivan, Ihsan] Cumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey -- [Parlak, Mesut] Sivas Numune Hosp, Dept Pharmacol, Sivas, Turkey -- [Celik, Cumali] Sivas Numune Hosp, Dept Internal Med, Sivas, Turkey -- [Ataseven, Hilmi] Sivas Numune Hosp, Dept Gastroenterol, Sivas, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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