dc.contributor.author | Bagci, Binnur | |
dc.contributor.author | Bagci, Gokhan | |
dc.contributor.author | Huzmeli, Can | |
dc.contributor.author | Sezgin, Ilhan | |
dc.contributor.author | Ozdemir, Ozturk | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:12Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:12Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0301-1623 | |
dc.identifier.issn | 1573-2584 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s11255-016-1293-0 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7278 | |
dc.description | WOS: 000378888900021 | en_US |
dc.description | PubMed ID: 27118566 | en_US |
dc.description.abstract | We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). A total of 225 CRF subjects undergoing hemodialysis and 201 healthy controls were enrolled in the study. CRF subjects were divided into three major subgroups according to comorbidities including HT (n = 127), DM (n = 65) and AS (n = 33). Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method. The II genotype and I allele frequencies of CX3CR1 V249I polymorphism were found significantly more frequent in CRF subjects, CRF subjects with DM and CRF subjects with AS compared with controls (p < 0.05 for all comparisons). G allele frequency of CCR5 polymorphism was found significantly more prevalent in CRF subjects with DM than that of controls. Further, GG genotype and G allele frequencies of CCR5 polymorphism were significantly more prevalent in CRF subjects with AS compared with controls (p < 0.05). We also explored these polymorphisms among CRF subjects with and without following comorbidities: HT, DM, AS. We found significant association between CRF subjects with HT and without HT in terms of genotype and allele frequencies of V249I polymorphism (p < 0.05). CX3CR1 T280M polymorphism was not found significantly different in none of the comparisons. These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/s11255-016-1293-0 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Chronic renal failure | en_US |
dc.subject | CCR5 | en_US |
dc.subject | CX3CR1 | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | Polymorphism | en_US |
dc.title | Associations of fractalkine receptor (CX3CR1) and CCR5 gene variants with hypertension, diabetes and atherosclerosis in chronic renal failure patients undergoing hemodialysis | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL UROLOGY AND NEPHROLOGY | en_US |
dc.contributor.department | [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, TR-58140 Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Adv Technol Res Ctr, TR-58140 Sivas, Turkey -- [Bagci, Gokhan -- Sezgin, Ilhan] Cumhuriyet Univ, Sch Med, Dept Med Genet, TR-58140 Sivas, Turkey -- [Huzmeli, Can] Cumhuriyet Univ, Sch Med, Div Nephrol, Dept Internal Med, TR-58140 Sivas, Turkey -- [Ozdemir, Ozturk] Canakkale Sekiz Mart Univ, Sch Med, Dept Med Genet, Canakkale, Turkey | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.endpage | 1170 | en_US |
dc.identifier.startpage | 1163 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |