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Causative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center study

Date

2016

Author

Hatipoglu, Mustafa
Mutluoglu, Mesut
Turhan, Vedat
Uzun, Gunalp
Lipsky, Benjamin A.
Sevim, Erol
Demiraslan, Hayati
Eryilmaz, Esma
Ozuguz, Cem
Memis, Ali
Ay, Hakan
Arda, Bilgin
Uysal, Serhat
Motor, Vicdan Koksaldi
Kader, Cigdem
Erturk, Ayse
Coskun, Omer
Duygu, Fazilet
Guler, Selma
Altay, Fatma Aybala
Ogutlu, Aziz
Bolukcu, Sibel
Yildiz, Senol
Kandemir, Ozlem
Aslaner, Halide
Polat, Arife
Karahocagil, Mustafa K.
Yasar, Kadriye Kart
Sehmen, Emine
Kilic, Sirri
Sunbul, Mustafa
Gencer, Serap
Bozkurt, Fatma
Yanik, Tugba
Oztoprak, Nefise
Batirel, Ayse
Sozen, Hamdi
Kilic, Inci
Celik, Ilhami
Ay, Bengisu
Tosun, Selma
Kadanali, Ayten
Comoglu, Senol
Denk, Affan
Hosoglu, Salih
Aydin, Ozlem
Elaldi, Nazif
Akalin, Serife
Kandemir, Bahar
Akbulut, Ayhan
Demirdal, Tuna
Balik, Recep
Azak, Emel
Sengoz, Gonul

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Abstract

Aim: Clinical practice guidelines for the management of diabetic foot infections developed by the Infectious Diseases Society of America (IDSA) are commonly used worldwide. The issue of whether or not these guidelines need to be adjusted for local circumstances, however, has seldom been assessed in large prospective trials. Methods: The Turk-DAY trial was a prospective, multi-center study in which infectious disease specialists from centers across Turkey were invited to participate (NCT02026830). Results: A total of 35 centers throughout Turkey enrolled patients in the trial. Overall, investigators collected a total of 522 specimens from infected diabetic foot wounds for culture from 447 individual patients. Among all isolates, 36.4% were gram-positive organisms, with Staphylococcus aureus the most common among these (11.4%). Gram-negative organisms constituted 60.2% of all the isolates, and the most commonly isolated gram-negative was Escherichia coli (15%). The sensitivity rates of the isolated species were remarkably low for several antimicrobials used in the mild infection group. Conclusions: Based on our findings, several of the antimicrobials frequently used for empirical treatment, including some also recommended in the IDSA guidelines, would not be optimal for treating diabetic foot infections in Turkey. Although the IDSA guideline recommendations may be helpful to guide empiric antimicrobial therapy of DFIs, they should be adjusted to local conditions. (C) 2016 Elsevier Inc. All rights reserved.

Source

JOURNAL OF DIABETES AND ITS COMPLICATIONS

Volume

30

Issue

5

URI

https://dx.doi.org/10.1016/j.jdiacomp.2016.02.013
https://hdl.handle.net/20.500.12418/7281

Collections

  • Makale Koleksiyonu [5200]
  • Makale Koleksiyonu [5745]
  • Öksüz Yayınlar Koleksiyonu - WoS [6162]



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