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dc.contributor.authorErsoy, Gulcin Sahin
dc.contributor.authorEken, Meryem
dc.contributor.authorTal, Reshef
dc.contributor.authorOztekin, Deniz
dc.contributor.authorDevranoglu, Belgin
dc.contributor.authorKaygusuz, Ecmel Isik
dc.contributor.authorCevik, Ozge
dc.descriptionWOS: 000380750600011en_US
dc.descriptionPubMed ID: 27083693en_US
dc.description.abstractThis study evaluated the effects of N-acetylcysteine (NAC) and enoxaparin on ovarian tissue preservation, ovarian reserve and oxidative damage following ovarian torsion/detorsion injury. Rats were divided into four groups (n = 6/group): control; ischaemia/reperfusion (I/R); I/R + NAC; I/R + enoxaparin. Twenty-four hours after detorsion, ovarian tissues were collected for histopathological analysis and measurement of tissue 8-OHdG, GSH, MDA, MPO and SOD concentrations, as well as pre- and post-operative circulating AMH concentrations. Administration of NAC resulted in more pre-antral follicles compared with enoxaparin treatment and haemorrhage and follicle cell degeneration were more pronounced in I/R + enoxaparin group than I/R + NAC group. Both NAC and enoxaparin led to a significant reduction in ovarian tissue 8-OHdG (P = 0.004 and P = 0.01, respectively) and MPO (P = 0.013 and P = 0.023, respectively) concentrations compared with I/R group, indicating a protective effect against I/R oxidative damage. Only NAC-treated animals showed a significant increase in GSH and SOD concentrations and decrease in MDA concentrations compared with I/R group (P = 0.007, P = 0.024 and P = 0.026, respectively). These results indicate that NAC is more effective than enoxaparin in minimizing ovarian damage and preserving ovarian reserve following ovarian torsion. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.publisherELSEVIER SCI LTDen_US
dc.subjectanti-Mullerian hormoneen_US
dc.subjectenoxaparin sodiumen_US
dc.subjectovarian ischaemia-reperfusionen_US
dc.subjectovarian reserveen_US
dc.titleN-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion modelen_US
dc.contributor.department[Ersoy, Gulcin Sahin] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Eken, Meryem -- Devranoglu, Belgin] Zeynep Kamil Educ & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Tal, Reshef] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, New Haven, CT USA -- [Oztekin, Deniz] Tepecik Educ & Res Hosp, Dept Obstet & Gynecol, Izmir, Turkey -- [Kaygusuz, Ecmel Isik] Zeynep Kamil Educ & Res Hosp, Dept Pathol, Istanbul, Turkey -- [Cevik, Ozge] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkeyen_US
dc.contributor.authorIDCevik, Ozge -- 0000-0002-9325-3757; Tal, Reshef -- 0000-0002-2500-9904; Sahin Ersoy, Gulcin -- 0000-0003-2354-3668en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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