Managing atypical and typical herpetic central nervous system infections: results of a multinational study
dc.contributor.author | Cag, Y. | |
dc.contributor.author | Erdem, H. | |
dc.contributor.author | Leib, S. | |
dc.contributor.author | Defres, S. | |
dc.contributor.author | Kaya, S. | |
dc.contributor.author | Larsen, L. | |
dc.contributor.author | Poljak, M. | |
dc.contributor.author | Ozturk-Engin, D. | |
dc.contributor.author | Barsic, B. | |
dc.contributor.author | Argemi, X. | |
dc.contributor.author | Sorensen, S. M. | |
dc.contributor.author | Bohr, A. L. | |
dc.contributor.author | Tattevin, P. | |
dc.contributor.author | Gunst, J. D. | |
dc.contributor.author | Bastakova, L. | |
dc.contributor.author | Jereb, M. | |
dc.contributor.author | Johansen, I. S. | |
dc.contributor.author | Karabay, O. | |
dc.contributor.author | Pekok, A. U. | |
dc.contributor.author | Sipahi, O. R. | |
dc.contributor.author | Chehri, M. | |
dc.contributor.author | Beraud, G. | |
dc.contributor.author | Shehata, G. | |
dc.contributor.author | Fontana, R. | |
dc.contributor.author | Maresca, M. | |
dc.contributor.author | Karsen, H. | |
dc.contributor.author | Sengoz, G. | |
dc.contributor.author | Sunbul, M. | |
dc.contributor.author | Yilmaz, G. | |
dc.contributor.author | Yilmaz, H. | |
dc.contributor.author | Sharif-Yakan, A. | |
dc.contributor.author | Kanj, S. | |
dc.contributor.author | Parlak, E. | |
dc.contributor.author | Pehlivanoglu, F. | |
dc.contributor.author | Korkmaz, F. | |
dc.contributor.author | Komur, S. | |
dc.contributor.author | Kose, S. | |
dc.contributor.author | Ulug, M. | |
dc.contributor.author | Bolukcu, S. | |
dc.contributor.author | Coskuner, S. A. | |
dc.contributor.author | Stahl, J. P. | |
dc.contributor.author | Ince, N. | |
dc.contributor.author | Akkoyunlu, Y. | |
dc.contributor.author | Halac, G. | |
dc.contributor.author | Sahin-Horasan, E. | |
dc.contributor.author | Tireli, H. | |
dc.contributor.author | Kilicoglu, G. | |
dc.contributor.author | Al-Mahdawi, A. | |
dc.contributor.author | Nemli, S. A. | |
dc.contributor.author | Inan, A. | |
dc.contributor.author | Senbayrak, S. | |
dc.contributor.author | Vahaboglu, H. | |
dc.contributor.author | Elaldi, N. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:23Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:23Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1198-743X | |
dc.identifier.issn | 1469-0691 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.cmi.2016.03.027 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7319 | |
dc.description | WOS: 000379252100027 | en_US |
dc.description | PubMed ID: 27085724 | en_US |
dc.description.abstract | There have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focussed on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70.8%), HSV-2 DNA in 83 patients (16.7%) and undefined HSV DNA type in 62 patients (12.5%). A total of 379 patients (76.4%) had at least one of the specified characteristics of encephalitis, and we placed these patients into the encephalitis presentation group. The remaining 117 patients (23.6%) had none of these findings, and these patients were placed in the nonencephalitis presentation group. Abnormalities suggestive of encephalitis were detected in magnetic resonance imaging (MRI) in 83.9% of the patients and in electroencephalography (EEG) in 91.0% of patients in the encephalitis presentation group. In the nonencephalitis presentation group, MRI and EEG data were suggestive of encephalitis in 33.3 and 61.9% of patients, respectively. However, the concomitant use of MRI and EEG indicated encephalitis in 96.3 and 87.5% of the cases with and without encephalitic clinical presentation, respectively. Considering the subtle nature of HME, CSF HSV PCR, EEG and MRI data should be collected for all patients with a central nervous system infection. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.relation.isversionof | 10.1016/j.cmi.2016.03.027 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Atypical presentation | en_US |
dc.subject | encephalitis | en_US |
dc.subject | herpes simplex virus | en_US |
dc.subject | managing | en_US |
dc.subject | meningitis | en_US |
dc.title | Managing atypical and typical herpetic central nervous system infections: results of a multinational study | en_US |
dc.type | article | en_US |
dc.relation.journal | CLINICAL MICROBIOLOGY AND INFECTION | en_US |
dc.contributor.department | [Cag, Y.] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, H.] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Leib, S.] Univ Bern, Inst Infect Dis, CH-3012 Bern, Switzerland -- [Defres, S.] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England -- [Defres, S.] Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Trop Infect Dis Unit, Liverpool, Merseyside, England -- [Kaya, S.] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Larsen, L. -- Johansen, I. S.] Odense Univ Hosp, Dept Infect Dis Q, Odense, Denmark -- [Poljak, M.] Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia -- [Ozturk-Engin, D. -- Bolukcu, S. -- Inan, A. -- Senbayrak, S.] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Barsic, B.] Univ Zagreb, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Sch Med, Zagreb, Croatia -- [Argemi, X.] Nouvel Hop Civil, Dept Infect Dis, Strasbourg, France -- [Sorensen, S. M.] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark -- [Bohr, A. L.] Rigshosp, Copenhagen Univ Hosp, Inst Inflammat Res, Dept Infect Dis & Rheumatol, Copenhagen, Denmark -- [Tattevin, P.] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France -- [Gunst, J. D.] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark -- [Bastakova, L.] Masaryk Univ, Fac Hosp Brno, Dept Infect Dis, Fac Med, Brno, Czech Republic -- [Jereb, M.] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia -- [Karabay, O.] Sakarya Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Sakarya, Turkey -- [Pekok, A. U.] Private Erzurum Sifa Hosp, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Sipahi, O. R.] Ege Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Izmir, Turkey -- [Chehri, M.] Hvidovre Univ Hosp, Dept Infect Dis, Copenhagen, Denmark -- [Beraud, G.] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France -- [Shehata, G.] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt -- [Fontana, R. -- Maresca, M.] Univ Catania, Infect Dis Sect, Dept Clin & Mol Biomed, Catania, Italy -- [Karsen, H.] Harran Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sanliurfa, Turkey -- [Sengoz, G. -- Pehlivanoglu, F.] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sunbul, M. -- Yilmaz, H.] Ondokuz Mayis Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Samsun, Turkey -- [Yilmaz, G.] Ankara Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Sharif-Yakan, A. -- Kanj, S.] Amer Univ Beirut, Med Ctr, Beirut, Lebanon -- [Parlak, E.] Ataturk Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Korkmaz, F.] Konya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Komur, S.] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Kose, S.] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Ulug, M.] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Coskuner, S. A.] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Stahl, J. P.] Univ Grenoble 1, Grenoble, France -- [Stahl, J. P.] Univ Hosp Grenoble, Dept Infect Dis, Grenoble, France -- [Ince, N.] Duzce Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Duzce, Turkey -- [Akkoyunlu, Y.] Bezmi Alem Vakif Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Halac, G.] Bezmi Alem Vakif Univ, Sch Med, Dept Neurol, Istanbul, Turkey -- [Sahin-Horasan, E.] Mersin Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Mersin, Turkey -- [Tireli, H.] Haydarpasa Numune Training & Res Hosp, Dept Neurol, Istanbul, Turkey -- [Kilicoglu, G.] Haydarpasa Numune Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Al-Mahdawi, A.] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq -- [Nemli, S. A.] Katip Celebi Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Izmir, Turkey -- [Vahaboglu, H.] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, N.] Cumhuriyet Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Sivas, Turkey | en_US |
dc.contributor.authorID | Ghaydaa, Shehata -- 0000-0002-3631-893X; VAHABOGLU, Haluk -- 0000-0001-8217-1767; Kanj, Souha -- 0000-0001-6413-3396; Beraud, Guillaume -- 0000-0002-4705-0916; Gunst, Jesper -- 0000-0002-3787-0259; Stahl, Jean Paul -- 0000-0002-0086-3557; johansen, isik somuncu -- 0000-0002-2189-9823; Larsen, Lykke -- 0000-0002-4113-4182; Karabay, Oguz -- 0000-0003-0502-432X; -- 0000-0002-1106-6123 | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 6 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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