Risk factors for infection with colistin-resistant gram-negative microorganisms: a multicenter study
dc.contributor.author | Yilmaz, Gul R. | |
dc.contributor.author | Dizbay, Murat | |
dc.contributor.author | Guven, Tumer | |
dc.contributor.author | Pullukcu, Husnu | |
dc.contributor.author | Tasbakan, Meltem | |
dc.contributor.author | Guzel, Ozlem Tunccan | |
dc.contributor.author | Tekce, Yasemin T. | |
dc.contributor.author | Ozden, Mehmet | |
dc.contributor.author | Turhan, Ozge | |
dc.contributor.author | Guner, Rahmet | |
dc.contributor.author | Cag, Yasemin | |
dc.contributor.author | Bozkurt, Fatma | |
dc.contributor.author | Karadag, Fatma Yilmaz | |
dc.contributor.author | Kartal, Elif Doyuk | |
dc.contributor.author | Gozel, Gokhan | |
dc.contributor.author | Bulut, Cemal | |
dc.contributor.author | Erdinc, Sebnem | |
dc.contributor.author | Keske, Siran | |
dc.contributor.author | Acikgoz, Ziya Cibali | |
dc.contributor.author | Tasyaran, Mehmet A. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:27Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:27Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0256-4947 | |
dc.identifier.issn | 1319-9226 | |
dc.identifier.uri | https://dx.doi.org/10.5144/0256-4947.2016.216 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7334 | |
dc.description | WOS: 000384907900008 | en_US |
dc.description | PubMed ID: 27236394 | en_US |
dc.description.abstract | BACKGROUND: Knowing risk factors for colistin resistance is important since colistin is the only remaining choice for the treatment of infections caused by multi-drug resistant microorganisms. OBJECTIVE: Evaluate risk factors associated with infection by colistin-resistant microorganisms. DESIGN: Retrospective study. SETTINGS: Tertiary healthcare centers. PATIENTS AND METHODS: An e-mail including the title and purpose of the study was sent to 1500 infectious disease specialists via a scientific and social web portal named "Infeksiyon Dunyasi (Infection World)". Demographic and clinical data was requested from respondents. MAIN OUTCOME MEASURE(S): Colistin-resistance. RESULTS: Eighteen infectious disease specialists from twelve tertiary care centers responded to the invitation. Data was collected on 165 patients, 56 cases (39.9%) and 109 (66.0%) age-and sex-matched controls. The colistin-resistant microorganisms isolated from cases were 29 Acinetobacter baumannii (51.8%), 18 Pseudomonas aeruginosa (32.1%) and 9 Klebsiella spp. Colistin, carbapenem, and quinolone use in the last three months were risk factors for colistin resistance in the univariate analysis. Previous quinolone use in the last three months (P=.003; RR: 3.2; 95% CI: 1.5-6,7) and previous colistin use in the last three months (P=.001; RR: 3.6; 95% CI: 1.63-7.99) were significant risk factors in the multivariate analysis. CONCLUSION: Clinicians should limit the use of quinolones and remain aware of the possibility of resistance developing during colistin use. LIMITATIONS: The lack of a heteroresistance analysis on the isolates. No data on use of a loading dose or the use of colistin in combination. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | K FAISAL SPEC HOSP RES CENTRE | en_US |
dc.relation.isversionof | 10.5144/0256-4947.2016.216 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Risk factors for infection with colistin-resistant gram-negative microorganisms: a multicenter study | en_US |
dc.type | article | en_US |
dc.relation.journal | ANNALS OF SAUDI MEDICINE | en_US |
dc.contributor.department | [Yilmaz, Gul R.] Ankara Ataturk Training & Res Hosp, Infect Dis & Clin Microbiol, TR Minist Hlth, Bilkent Cad 3, TR-06800 Ankara, Turkey -- [Dizbay, Murat -- Guzel, Ozlem Tunccan] Gazi Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Guven, Tumer -- Guner, Rahmet -- Tasyaran, Mehmet A.] Yildirim Beyazit Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Pullukcu, Husnu -- Tasbakan, Meltem] Ege Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Tekce, Yasemin T.] Turkiye Yuksek Ihtisas Training & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Ozden, Mehmet] Firat Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Turhan, Ozge] Akdeniz Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Antalya, Turkey -- [Cag, Yasemin] Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Bozkurt, Fatma] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Karadag, Fatma Yilmaz] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Fac Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kartal, Elif Doyuk] Osmangazi Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Eskicehir, Turkey -- [Gozel, Gokhan] Cumhuriyet Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Sivas, Turkey -- [Bulut, Cemal -- Erdinc, Sebnem] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Keske, Siran] Giresun Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Giresun, Turkey -- [Acikgoz, Ziya Cibali] Yildirim Beyazit Univ, Dept Microbiol, Fac Med, Ankara, Turkey | en_US |
dc.contributor.authorID | Keske, Siran -- 0000-0003-3823-4454; Gozel, Mustafa Gokhan -- 0000-0001-5187-7388; Dizbay, Murat -- 0000-0003-4120-0781 | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 222 | en_US |
dc.identifier.startpage | 216 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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