dc.contributor.author | Tutar, Ugur | |
dc.contributor.author | Celik, Cem | |
dc.contributor.author | Karaman, Isa | |
dc.contributor.author | Atas, Mehmet | |
dc.contributor.author | Hepokur, Ceylan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:32Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:32Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1596-5996 | |
dc.identifier.uri | https://dx.doi.org/10.4314/tjpr.v15i5.20 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7353 | |
dc.description | WOS: 000376757300020 | en_US |
dc.description.abstract | Purpose: To investigate the antimicrobial and anti-biofilm activities of essential oil from Mentha pulegieum L. (EOMP) on multi-drug resistant (MDR) isolates of A. baumannii, as well as its phytochemical composition, antioxidant properties and cytotoxic activity. Methods: The phytochemical composition of EOMP was analyzed by gas chromatography, while its antimicrobial activities were determined by disc diffusion and broth micro-dilution methods. Minimal biofilm inhibition concentration (MBIC) and minimal biofilm eradication concentration (MBEC) tests were used for assessment of its anti-biofilm properties. Viability in the biofilm was studied using 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay, while colorimetric assay was used to assess its cytotoxicity on L929 cells Results: D-isomenthone, pulegone, isopulegone, menthol and piperitenone were the major components of the plant extract. EOMP produced > 22 mm inhibition zone for the isolates, with minimum inhibitory concentration (MIC) and MBIC of 0.6 -2.5 and 0.6 -1.25 mu L/mL, respectively, while MBEC was >= 10 mu L/msL. EOMP damaged biofilm structures formed by A. baumannii strains at MIC by 26 - 91 %. Conclusion: These results suggest that EOMP contains agents that may be useful in the development of new drugs against A. baumannii infections. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PHARMACOTHERAPY GROUP | en_US |
dc.relation.isversionof | 10.4314/tjpr.v15i5.20 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Mentha pulegium | en_US |
dc.subject | Essential oil | en_US |
dc.subject | Anti-biofilm | en_US |
dc.subject | Antimicrobial activity | en_US |
dc.subject | Multi-drug resistance | en_US |
dc.subject | A. baumannii | en_US |
dc.title | Anti-biofilm and antimicrobial activity of Mentha pulegium L essential oil against multidrug-resistant Acinetobacter baumannii | en_US |
dc.type | article | en_US |
dc.relation.journal | TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | en_US |
dc.contributor.department | [Tutar, Ugur] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Dietet, Sivas, Turkey -- [Celik, Cem] Cumhuriyet Univ, Fac Med, Dept Med Microbiol, Sivas, Turkey -- [Karaman, Isa] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Bioengn, Tokat, Turkey -- [Atas, Mehmet] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Microbiol, Sivas, Turkey -- [Hepokur, Ceylan] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkey | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | U211 | en_US |
dc.identifier.startpage | 1039 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |