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dc.contributor.authorBasbug, Onur
dc.contributor.authorAgaoglu, Zahid T.
dc.contributor.authorTuzcu, Nevin
dc.contributor.authorCoskun, Alparslan
dc.contributor.authorAydogdu, Ugur
dc.contributor.authorYigin, Akin
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:36Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:36Z
dc.date.issued2016
dc.identifier.issn1300-6045
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2015.14896
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7365
dc.descriptionWOS: 000374312100015en_US
dc.description.abstractLumpy skin disease (LSD) is a viral disease of cattle, characterised by the formation of nodules in different parts of the body. In this study, it was conducted to assess the pattern of changes of albumin, tumour necrosis factor-alpha (TNF-alpha), haptoglobin (Hp), serum amyloid A (SAA) and neopterin levels in cattle with LSD, to assess the clinical course of the disease, and to the demonstration of inflammatory process in cattle with LSD. This study was carried out in 30 cattle, including 20 animals naturally infected with LSD and 10 healthy animals. It was determined that, in the cattle infected with LSD, while albumin concentrations had significantly decreased (P=0.004) in comparison to the control group, Hp (P<0.001), SAA (P<0.001) and neopterin (P<0.001) concentrations had significantly increased. Receiver operating characteristic (ROC) curve was used to calculate the sensitivity and specificity of Hp, SAA and neopterin. The cut-off values of the healthy and infected cattle for Hp, SAA and neopterin were determined to be 0.196 mg/mL, 41.38 mu g/mL and 23.93 nmol/mL, respectively. At these cut-off values, high levels of sensitivity (85% for Hp, 95% for SAA and 70% for neopterin) and specificity (90%) were detected. It was determined that SAA levels were of higher sensitivity and specificity compared to Hp and neopterin levels with respect to the demonstration of inflammation associated with LSD. Furthermore, the clinical picture of the disease was found to be significantly correlated with the Hp, SAA and neopterin levels.en_US
dc.language.isoengen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.isversionof10.9775/kvfd.2015.14896en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLumpy Skin Diseaseen_US
dc.subjectAcute phaseen_US
dc.subjectNeopterinen_US
dc.subjectCattleen_US
dc.titleTumour Necrosis Factor-alpha, Haptoglobin, Serum Amyloid A and Neopterin Levels in Cattle with Lumpy Skin Diseaseen_US
dc.typearticleen_US
dc.relation.journalKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.contributor.department[Basbug, Onur -- Agaoglu, Zahid T. -- Coskun, Alparslan -- Aydogdu, Ugur] Cumhuriyet Univ, Dept Internal Dis, Fac Vet Med, TR-58140 Sivas, Turkey -- [Tuzcu, Nevin] Cumhuriyet Univ, Dept Pharmaceut Microbiol, Fac Pharm, TR-58140 Sivas, Turkey -- [Yigin, Akin] Harran Univ, Fac Vet Med, Depertmant Genet, TR-63300 Sanliurfa, Turkeyen_US
dc.identifier.volume22en_US
dc.identifier.issue3en_US
dc.identifier.endpage424en_US
dc.identifier.startpage417en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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