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dc.contributor.authorYuce, Salim
dc.contributor.authorSancakdar, Enver
dc.contributor.authorBagci, Gokhan
dc.contributor.authorKoc, Sema
dc.contributor.authorKurtulgan, Hande Kucuk
dc.contributor.authorBagci, Binnur
dc.contributor.authorDogan, Mansur
dc.contributor.authorUysal, Ismail Onder
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:40Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:40Z
dc.date.issued2016
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.urihttps://dx.doi.org/10.5152/iao.2016.1732
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7380
dc.descriptionWOS: 000384907700014en_US
dc.descriptionPubMed ID: 27340988en_US
dc.description.abstractOBJECTIVE: Tinnitus is described as a disturbing sound sensation in the absence of external stimulation. We aimed to investigate whether there is any relationship between severe chronic tinnitus and angiotensin-converting enzyme (ACE) I/D and alpha-adducin (ADD1) G460W gene polymorphisms. MATERIALS and METHODS: The patient group and control group consisted of 89 and 104 individuals, respectively. The evaluation of tinnitus was performed using the Strukturiertes Tinnitus-Interview (STI). The Tinnitus Handicap Inventory (THI) was used to evaluate the tinnitus severity. Polymerase chain reaction (PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques were used for genotyping. RESULTS: With regard to the ACE I/D polymorphism, there was no significant difference in genotype and allele frequencies between the patient group and control group. However, a statistically significant difference was found in genotype (p< 0.01) and allele frequencies (p= 0.021) of the ADD1 G460W gene polymorphism. Combined genotype analysis showed that the ACE II /ADD1 GW genotype was statistically significantly higher in the patient group than in the control group (X2: 7.15, p= 0.007). The odds ratio value of the GW genotype was 2.5 (95% CI= 1.4-4.7) (p< 0.01). CONCLUSION: Our results demonstrate an association between ADD1 G460W gene polymorphism and susceptibility to severe chronic tinnitus. It was found that the GW genotype increased the disease risk by 2.5-fold compared with other genotypes. This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.en_US
dc.language.isoengen_US
dc.publisherAVESen_US
dc.relation.isversionof10.5152/iao.2016.1732en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTinnitusen_US
dc.subjectACEen_US
dc.subjectADD1en_US
dc.subjectpolymorphismen_US
dc.titleAngiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms in Turkish Patients with Severe Chronic Tinnitusen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF INTERNATIONAL ADVANCED OTOLOGYen_US
dc.contributor.department[Yuce, Salim -- Dogan, Mansur -- Uysal, Ismail Onder] Cumhuriyet Univ, Sch Med, Dept Otorhinolaryngol, Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Bagci, Gokhan -- Kurtulgan, Hande Kucuk] Cumhuriyet Univ, Sch Med, Dept Med Genet, Sivas, Turkey -- [Koc, Sema] Antalya Training & Res Hosp, Dept Ear Nose Throat Head & Neck Surg, Antalya, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, Sivas, Turkeyen_US
dc.contributor.authorIDKurtulgan, Hande Kucuk -- 0000-0001-9172-3244en_US
dc.identifier.volume12en_US
dc.identifier.issue1en_US
dc.identifier.endpage81en_US
dc.identifier.startpage77en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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