Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms in Turkish Patients with Severe Chronic Tinnitus
dc.contributor.author | Yuce, Salim | |
dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Bagci, Gokhan | |
dc.contributor.author | Koc, Sema | |
dc.contributor.author | Kurtulgan, Hande Kucuk | |
dc.contributor.author | Bagci, Binnur | |
dc.contributor.author | Dogan, Mansur | |
dc.contributor.author | Uysal, Ismail Onder | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:40Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:40Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1308-7649 | |
dc.identifier.issn | 2148-3817 | |
dc.identifier.uri | https://dx.doi.org/10.5152/iao.2016.1732 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7380 | |
dc.description | WOS: 000384907700014 | en_US |
dc.description | PubMed ID: 27340988 | en_US |
dc.description.abstract | OBJECTIVE: Tinnitus is described as a disturbing sound sensation in the absence of external stimulation. We aimed to investigate whether there is any relationship between severe chronic tinnitus and angiotensin-converting enzyme (ACE) I/D and alpha-adducin (ADD1) G460W gene polymorphisms. MATERIALS and METHODS: The patient group and control group consisted of 89 and 104 individuals, respectively. The evaluation of tinnitus was performed using the Strukturiertes Tinnitus-Interview (STI). The Tinnitus Handicap Inventory (THI) was used to evaluate the tinnitus severity. Polymerase chain reaction (PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques were used for genotyping. RESULTS: With regard to the ACE I/D polymorphism, there was no significant difference in genotype and allele frequencies between the patient group and control group. However, a statistically significant difference was found in genotype (p< 0.01) and allele frequencies (p= 0.021) of the ADD1 G460W gene polymorphism. Combined genotype analysis showed that the ACE II /ADD1 GW genotype was statistically significantly higher in the patient group than in the control group (X2: 7.15, p= 0.007). The odds ratio value of the GW genotype was 2.5 (95% CI= 1.4-4.7) (p< 0.01). CONCLUSION: Our results demonstrate an association between ADD1 G460W gene polymorphism and susceptibility to severe chronic tinnitus. It was found that the GW genotype increased the disease risk by 2.5-fold compared with other genotypes. This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AVES | en_US |
dc.relation.isversionof | 10.5152/iao.2016.1732 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Tinnitus | en_US |
dc.subject | ACE | en_US |
dc.subject | ADD1 | en_US |
dc.subject | polymorphism | en_US |
dc.title | Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms in Turkish Patients with Severe Chronic Tinnitus | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY | en_US |
dc.contributor.department | [Yuce, Salim -- Dogan, Mansur -- Uysal, Ismail Onder] Cumhuriyet Univ, Sch Med, Dept Otorhinolaryngol, Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Bagci, Gokhan -- Kurtulgan, Hande Kucuk] Cumhuriyet Univ, Sch Med, Dept Med Genet, Sivas, Turkey -- [Koc, Sema] Antalya Training & Res Hosp, Dept Ear Nose Throat Head & Neck Surg, Antalya, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, Sivas, Turkey | en_US |
dc.contributor.authorID | Kurtulgan, Hande Kucuk -- 0000-0001-9172-3244 | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 81 | en_US |
dc.identifier.startpage | 77 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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