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dc.contributor.authorUslu, Ali Ugur
dc.contributor.authorYonem, Ozlem
dc.contributor.authorAydin, Bahattin
dc.contributor.authorUncu, Tunahan
dc.contributor.authorSeven, Dogan
dc.contributor.authorBalta, Sevket
dc.contributor.authorCicekli, Emre
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:42Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:42Z
dc.date.issued2016
dc.identifier.issn1607-551X
dc.identifier.issn2410-8650
dc.identifier.urihttps://dx.doi.org/10.1016/j.kjms.2016.03.009
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7385
dc.descriptionWOS: 000376445200008en_US
dc.descriptionPubMed ID: 27185605en_US
dc.description.abstractSystematic inflammation, enhanced oxidative stress, and endothelial dysfunction are important for evolution and progression of renal damage, and they cause an increase in red cell distribution width (RDW). Familial Mediterranean fever (FMF) patients who are in the attack-free period and its relation with albuminuria and performance on assessment of microalbuminuria. One hundred and seventy-seven patients who had been diagnosed in accordance with Tel-hoshmer criteria and were in the attack-free period, and 143 age-and sex-matched healthy individuals were enrolled in our study. RDW values of FMF patients were higher compared with those of the controls (13.85 +/- 1.07 and 13.15 +/- 0.91, respectively; p < 0.0001). RDW values of FMF patients with microalbuminuria were higher compared with those of FMF patients with normoalbuminuria and the control group (p = 0.002 and p < 0.0001, respectively). RDW values of FMF patients with normoalbuminuria were higher compared with those of the control group (p < 0.0001). We have showed RDW levels are positively correlated with albuminuria (r = 0.185, p = 0.014). When assessing microalbuminuria with RDW in the patients, a cutoff value of 13.85 with sensitivity of 60%, specificity of 62%, and p = 0.002 (area under curve: 0.651, 95% confidence interval 0.563-0.738), was observed according to receiver-operating characteristic curve analysis. Among the various variables associated with albuminuria in multivariate logistic regression analyses, RDW remained an independent predictor of albuminuria (95% confidence interval 0.479-0.942, p = 0.021). RDW may be associated with albuminuria in FMF patients and it can be a predictor of microalbuminuria. Copyright (C) 2016, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.en_US
dc.language.isoengen_US
dc.publisherWILEYen_US
dc.relation.isversionof10.1016/j.kjms.2016.03.009en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlbuminuriaen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectMicroalbuminuriaen_US
dc.subjectRed cell distribution widthen_US
dc.subjectSystemic inflammationen_US
dc.titleRed cell distribution width is associated with albuminuria in adults with familial Mediterranean feveren_US
dc.typearticleen_US
dc.relation.journalKAOHSIUNG JOURNAL OF MEDICAL SCIENCESen_US
dc.contributor.department[Uslu, Ali Ugur] Eskisehir Mil Hosp, Dept Internal Med, Eskisehir, Turkey -- [Yonem, Ozlem] Cumhuriyet Univ, Fac Med, Dept Gastroenterol, Sivas, Turkey -- [Aydin, Bahattin] Etimesgut Mil Hosp, Dept Internal Med, Ankara, Turkey -- [Uncu, Tunahan -- Seven, Dogan -- Cicekli, Emre] Cumhuriyet Univ, Fac Med, Dept Internal Med, Sivas, Turkey -- [Balta, Sevket] Gulhane Med Acad Ankara, Dept Cardiol, Ankara, Turkeyen_US
dc.identifier.volume32en_US
dc.identifier.issue4en_US
dc.identifier.endpage220en_US
dc.identifier.startpage216en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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