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dc.contributor.authorYucel, Hasan
dc.contributor.authorZorlu, Ali
dc.contributor.authorKaya, Hakki
dc.contributor.authorYilmaz, Mehmet Birhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:50Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:50Z
dc.date.issued2016
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.urihttps://dx.doi.org/10.5152/akd.2015.6093
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7411
dc.descriptionWOS: 000377193000003en_US
dc.descriptionPubMed ID: 26467374en_US
dc.description.abstractObjective: Endothelial dysfunction, secondary to systemic inflammation and oxidative stress, is known to play a major role in the development and progression of atherosclerosis. It is hypothesized that the lower incidence of coronary artery disease in the premenopausal period in females when compared with males is associated with regular menstrual blood loss. We investigated whether regular blood donation (BD) is associated with improved endothelial function in healthy adult males. Methods: Fifty young healthy male volunteers volunteers with a mean age of 30 +/- 6 years without overt cardiovascular disease were enrolled to participate in serial consecutive BDs. Serum iron levels as oxidative stress parameters, flow-mediated dilatation (FMD) for endothelial function, 24-h mean diastolic blood pressure for peripheral vascular resistance identification, and high-sensitivity C-reactive protein (hs-CRP) levels as systemic inflammatory markers were evaluated before and after BD. This study used a prospective observational cohort design. Patients with cardiovascular and inflammatory diseases were excluded. Results: BD was found to improve FMD steadily and significantly when compared with the baseline (mean +/- SD: 9.9%+/- 3.8%, 10.44%+/- 3.9%, 10.65%+/- 3.9%, and 10.75 +/- 3.9%, respectively, p=0.15, p=0.02, p=0.006 as compared with the baseline). A steady decrease was identified in hs-CRP levels after serial BDs, although this decrease was not statistically significant in the all phases (2.96 +/- 3.3 mg/L, 2.26 +/- 1.5 mg/L, and 2.12 +/- 1.5 mg/L, respectively, p=0.829, p=0.558). The 24-h mean diastolic blood pressures were significantly lower in the chronic phase (77 +/- 9 mm Hg, 75 +/- 7 mm Hg, and 72 +/- 8 mm Hg, respectively, p=0.50, p=0.003), whereas there was no significant change in iron levels in the acute and chronic phases (66 +/- 32 mg/dL, 72 +/- 43 mg/dL, and 68 +/- 33 mg/dL, respectively, p=1.000, p=1.000). Conclusion: The results of the study indicate that regular BD improves endothelial function.en_US
dc.language.isoengen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.isversionof10.5152/akd.2015.6093en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectblood donationen_US
dc.subjectendothelial functionen_US
dc.subjectatherosclerosisen_US
dc.subjectflow-mediated vasodilatationen_US
dc.subjectironen_US
dc.titleRegular blood donation improves endothelial function in adult malesen_US
dc.typearticleen_US
dc.relation.journalANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.contributor.department[Yucel, Hasan -- Zorlu, Ali -- Kaya, Hakki -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkeyen_US
dc.contributor.authorIDYILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628en_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.endpage158en_US
dc.identifier.startpage154en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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