dc.contributor.author | Kanbur, Murat | |
dc.contributor.author | Silig, Yavuz | |
dc.contributor.author | Eraslan, Gokhan | |
dc.contributor.author | Karabacak, Mursel | |
dc.contributor.author | Sarica, Zeynep Soyer | |
dc.contributor.author | Aahin, Serap | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:52Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:52Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0944-1344 | |
dc.identifier.issn | 1614-7499 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s11356-015-5720-z | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7417 | |
dc.description | WOS: 000373609300023 | en_US |
dc.description | PubMed ID: 26561326 | en_US |
dc.description.abstract | In this study, the effects of cypermethrin (CYP), amitraz (AMT) and combined cypermethrin-amitraz (CYP-AMT) on some serum biochemical, oxidative stress and drug-metabolising parameters were investigated in male Wistar albino rats. CYP, AMT and combined CYP-AMT were administered at doses of 80 mg kg(-1) bw(-1) of CYP and 170 mg kg(-1) bw(-1) of AMT for 1 day (single dose), and at doses of 12 mg kg(-1) bw(-1) of CYP and 25 mg kg(-1) bw(-1) of AMT for 40 days by oral gavage. Oxidative stress (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glucose-6-phosphate dehydrogenase (G6PD)), serum biochemical (glucose, triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), blood urea nitrogen (BUN), creatinine, asparatate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein, albumin) in blood/tissues (liver, kidney, brain, spleen and testis) and hepatic drug-metabolising (cytochrome P450 2E1 (CYP2E1), NADH-cytochrome b(5) reductase (CYPb5), NADPH-cytochrome c reductase/NADPH cytocrome P450 reductase (CYTC), glutathione S-transferase (GST), glutathione (GSH)) parameters were measured in liver samples taken on days 1 and 40. In result, it was determined that CYP, AMT and their combinations led to significant changes in the parameters investigated, and it was ascertained that long-term exposure to insecticides and the administration of insecticide combinations produced greater toxic effects in comparison with the administration of insecticides alone. | en_US |
dc.description.sponsorship | Erciyes University [TSA-091132] | en_US |
dc.description.sponsorship | This research (project code: TSA-091132) was supported by the Research Fund of Erciyes University. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.relation.isversionof | 10.1007/s11356-015-5720-z | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Toxicity | en_US |
dc.subject | Cypermethrin | en_US |
dc.subject | Amitraz | en_US |
dc.subject | Combination | en_US |
dc.subject | Rat | en_US |
dc.title | The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | en_US |
dc.contributor.department | [Kanbur, Murat -- Eraslan, Gokhan] Erciyes Univ, Fac Vet Med, Dept Pharmacol & Toxicol, Kayseri, Turkey -- [Silig, Yavuz] Cumhuriyet Univ, Dept Biochem, Fac Med, Sivas, Turkey -- [Karabacak, Mursel] Erciyes Univ, Dept Anim Hlth, Safiye Cikrikcioglu Vacat Coll, Kayseri, Turkey -- [Sarica, Zeynep Soyer] Erciyes Univ, Hakan Cetinsaya Expt Anim Ctr, Kayseri, Turkey -- [Aahin, Serap] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkey | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 5242 | en_US |
dc.identifier.startpage | 5232 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |