dc.contributor.author | Dogan, Halef Okan | |
dc.contributor.author | Zungun, Cevdet | |
dc.contributor.author | Yilmaz, Fatma Meric | |
dc.contributor.author | Kayalp, Damla | |
dc.contributor.author | Zararsiz, Gokmen | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:54Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:54Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2149-2247 | |
dc.identifier.issn | 2149-2549 | |
dc.identifier.uri | https://dx.doi.org/10.5152/etd.2016.0060 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7426 | |
dc.description | WOS: 000372329600005 | en_US |
dc.description.abstract | Objective: Factor V (FV) (1691 G-A) and methylenetetrahydrofolate reductase (MTHFR) (677 C-T) mutations have been identified as potential risk factors for cardiovascular disease. In this study, we determined vitamin B-12, folate, and total homocysteine t(Hcy) concentrations in heterozygote MTHFR (677 C-T) and FV (1691 G-A) mutation-carrying individuals. Materials and Methods: The study included a total of 74 individuals with MTHFR (677 C-T) or FV (1691 G-A) mutations and 70 controls. All subjects had the history of thromboembolic disease. t(Hcy), folate, and vitamin B-12 concentrations were compared between the groups. Results: A significant difference was found in vitamin B-12 and folate concentrations between patients and controls in the MTHFR (677 C-T) group (p=0.041, p=0.049, respectively). Further, t(Hcy) concentrations were found to be higher in patients than in controls in the FV (1691 G-A) mutation-carrying group (p=0.002). No significant difference was found between the groups in relation with gender in both mutations. Conclusion: t(Hcy) concentrations should be assessed to decrease the risk of future venous thromboembolism in the presence of heterozygote FV (1691 G-A) mutation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AVES | en_US |
dc.relation.isversionof | 10.5152/etd.2016.0060 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Homocysteine | en_US |
dc.subject | Vitamin B-12 | en_US |
dc.subject | Folate | en_US |
dc.subject | MTHFR | en_US |
dc.subject | Factor V | en_US |
dc.title | Homocysteine Concentrations in Heterozygote MTHFR (677C-T) and Factor V (1691 G-A) Mutation-carrying Individuals with the History of Thromboembolic Disease | en_US |
dc.type | article | en_US |
dc.relation.journal | ERCIYES MEDICAL JOURNAL | en_US |
dc.contributor.department | [Dogan, Halef Okan] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Zungun, Cevdet] Sanliurfa Balikligol State Hosp, Biochem Lab, Sanliurfa, Turkey -- [Yilmaz, Fatma Meric] Yildirim Beyazit Univ, Sch Med, Dept Clin Biochem, Ankara, Turkey -- [Kayalp, Damla] Ankara Numune Training & Res Hosp, Dept Clin Biochem, Ankara, Turkey -- [Zararsiz, Gokmen] Erciyes Univ, Sch Med, Dept Biostat & Med Informat, Kayseri, Turkey | en_US |
dc.contributor.authorID | Zararsiz, Gokmen -- 0000-0001-5801-1835 | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 24 | en_US |
dc.identifier.startpage | 20 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |