The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
dc.contributor.author | Kucuk, Adem | |
dc.contributor.author | Erol, Mehmet Fatih | |
dc.contributor.author | Senel, Soner | |
dc.contributor.author | Eroler, Emir | |
dc.contributor.author | Yumun, Havvanur Alparslan | |
dc.contributor.author | Uslu, Ali Ugur | |
dc.contributor.author | Erol, Asiye Mukaddes | |
dc.contributor.author | Tihan, Deniz | |
dc.contributor.author | Duman, Ugur | |
dc.contributor.author | Kucukkartallar, Tevfik | |
dc.contributor.author | Solak, Yalcin | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:55Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:55Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1226-3303 | |
dc.identifier.issn | 2005-6648 | |
dc.identifier.uri | https://dx.doi.org/10.3904/kjim.2015.039 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7427 | |
dc.description | WOS: 000372174600020 | en_US |
dc.description | PubMed ID: 26864298 | en_US |
dc.description.abstract | Background/Aims: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lymphocyte ratio (NLR) to leverage the differential diagnosis of acute FMF attack with histologically proven appendicitis. Methods: Twenty-three patients with histologically confirmed acute appendicitis and 88 patients with acute attack of FMF were included in the study. NLR, C-reactive protein and other hematologic parameters were compared between the groups. Results: Neutrophil to lymphocyte ratio was significantly higher in patients with acute appendicitis compared to the FMF attack group (8.24 +/- 6.31 vs. 4.16 +/- 2.44, p = 0.007). The performance of NLR in diagnosing acute appendicitis with receiver operating characteristic analysis with a cut-off value of 4.03 were; 78% sensitivity, 62% specificity, and area under the curve 0.760 (95% confidence interval, 0.655 to 0.8655; p < 0.001). Conclusions: This study showed that NLR, the simple and readily available inflammatory marker may have a useful role in distinguishing acute FMF attack from acute appendicitis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | en_US |
dc.relation.isversionof | 10.3904/kjim.2015.039 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Neutrophil-to-lymphocyte ratio | en_US |
dc.subject | Familial Mediterranean fever attack | en_US |
dc.subject | Acute appendicitis | en_US |
dc.subject | Abdominal pain | en_US |
dc.subject | Inflammation | en_US |
dc.title | The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis | en_US |
dc.type | article | en_US |
dc.relation.journal | KOREAN JOURNAL OF INTERNAL MEDICINE | en_US |
dc.contributor.department | [Kucuk, Adem] Necmettin Erbakan Univ, Dept Internal Med, Div Rheumatol, Konya, Turkey -- [Erol, Mehmet Fatih -- Eroler, Emir -- Yumun, Havvanur Alparslan -- Tihan, Deniz -- Duman, Ugur] Bursa Sevket Yilmaz Res & Training Hosp, Dept Gen Surg, Bursa, Turkey -- [Senel, Soner] Cumhuriyet Univ, Dept Internal Med, Div Rheumatol, Sivas, Turkey -- [Uslu, Ali Ugur] Cumhuriyet Univ, Dept Internal Med, Sivas, Turkey -- [Erol, Asiye Mukaddes] Bursa Sevket Yilmaz Res & Training Hosp, Dept Phys Med & Rehabil, Bursa, Turkey -- [Kucukkartallar, Tevfik] Necmettin Erbakan Univ, Dept Gen Surg, Konya, Turkey -- [Solak, Yalcin] Necmettin Erbakan Univ, Dept Internal Med, Div Nephrol, Konya, Turkey -- [Solak, Yalcin] Sakarya Univ Res & Training Hosp, Dept Internal Med, Div Nephrol, Sakarya, Turkey | en_US |
dc.contributor.authorID | Duman, Ugur -- 0000-0002-4946-555X | en_US |
dc.identifier.volume | 31 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 391 | en_US |
dc.identifier.startpage | 386 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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