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dc.contributor.authorKaya, Hakki
dc.contributor.authorZorlu, Ali
dc.contributor.authorYucel, Hasan
dc.contributor.authorTatlisu, Mustafa Adem
dc.contributor.authorKivrak, Tarik
dc.contributor.authorCoskun, Abuzer
dc.contributor.authorYilmaz, Mehmet Birhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:46:04Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:46:04Z
dc.date.issued2016
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.urihttps://dx.doi.org/10.2143/AC.71.1.3132099
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7455
dc.descriptionWOS: 000370580300010en_US
dc.descriptionPubMed ID: 26853255en_US
dc.description.abstractIntroduction Atrial fibrillation (AF) is a common arrhythmia in heart failure (HF). Recent studies have shown that serum cancer antigen-125 (CA-125) levels are elevated in HF, and high levels of CA-125 in HF patients with sinus rhythm have been shown to be associated with the development of new onset AF. However, the relation between CA-125 levels and the presence of AF in HF is unknown. In this study we investigated whether plasma CA-125 levels in patients with systolic HF could predict the presence of AF. Methods The study was a retrospective cohort design including 205 stable systolic HF patients who were selected during outpatient clinic visits and who had CA-125 measurement and an electrocardiogram within the last one month before admittance to cardiology clinic. Patients were classified into two groups based on the presence of AF (n=67) or sinus rhythm (n=138). Results The mean age of the patients was 68 11 years. CA-125 levels were significantly higher in patients with AF than patients with SR [33 (3-273) vs 102 (7-296) U/ml, P < 0.001]. CA-125 level, presence of right ventricular dilatation, pericardial effusion, moderate to severe TR and MR, and left atrial diameter were found to be associated with the presence of AF in univariate analysis. In a multivariate logistic regression model, only the CA-125 level remained associated. Also, according to the ROC curve analysis, the optimal cut-off level of CA-125 for predicting AF was 91 U/mL with a specificity of 84% and a sensitivity of 54%. Conclusion We have shown that the CA-125 levels can be used to predict AF in patients with systolic HF.en_US
dc.language.isoengen_US
dc.publisherACTA CARDIOLOGICAen_US
dc.relation.isversionof10.2143/AC.71.1.3132099en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer antigen-125en_US
dc.subjectCA-125en_US
dc.subjectsystolic heart failureen_US
dc.subjectatrial fibrillationen_US
dc.titleHigher cancer antigen 125 level is associated with the presence of permanent atrial fibrillation in systolic heart failure patientsen_US
dc.typearticleen_US
dc.relation.journalACTA CARDIOLOGICAen_US
dc.contributor.department[Kaya, Hakki -- Zorlu, Ali -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ Med Sch, Dept Cardiol, Sivas, Turkey -- [Yucel, Hasan -- Tatlisu, Mustafa Adem] Sivas State Hosp, Dept Cardiol, Sivas, Turkey -- [Kivrak, Tarik] Sivas State Hosp, Dept Emergency, Sivas, Turkeyen_US
dc.contributor.authorIDYILMAZ, Mehmet Birhan -- 0000-0002-8169-8628; YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628en_US
dc.identifier.volume71en_US
dc.identifier.issue1en_US
dc.identifier.endpage66en_US
dc.identifier.startpage61en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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