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dc.contributor.authorKarakus, Savas
dc.contributor.authorAkkar, Ozlem Bozoklu
dc.contributor.authorYildiz, Caglar
dc.contributor.authorSancakdar, Enver
dc.contributor.authorCetin, Meral
dc.contributor.authorCetin, Ali
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:46:06Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:46:06Z
dc.date.issued2016
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-015-3803-1
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7460
dc.descriptionWOS: 000368019200013en_US
dc.descriptionPubMed ID: 26138305en_US
dc.description.abstractWe aimed to compare the serum levels of ET-1, M30, and Angs-1 and -2 in patients with preeclampsia or HELLP syndrome, and normal controls. In this cross-sectional study of 74 pregnant women, serum levels of ET-1, M30, and Angs-1 and -2 were measured in preeclamptic patients with or without HELLP syndrome. 74 pregnant women; 37 had healthy pregnancies, 25 had preeclampsia (PE), and 12 had HELLP syndrome. The age, body mass index, gravidity, and parity of patients with normal pregnancy, PE, and HELLP syndrome were comparable (p > 0.05). In HELLP syndrome, compared to healthy or preeclamptic pregnancies, platelet count was lower (p < 0.05) and the values of hepatic function tests were higher (p < 0.05). In HELLP syndrome, ET-1, M30, and Ang-2 were higher compared to healthy or preeclamptic pregnancies (p < 0.05); however, they increased in preeclamptic pregnancies compared to healthy pregnancies though not significant (p > 0.05). In PE or HELLP syndrome, Ang-1 was higher compared to a healthy pregnancy (p < 0.05); however, in HELLP syndrome, it was also higher than in PE though not significant (p > 0.05). We found no significant correlation among these biomarkers and hematological and biochemical parameters (p > 0.05). For the diagnosis of HELLP syndrome, increased levels of ET-1, M30, and Angs-1 and -2 appear as promising biomarkers after determination of their standardized threshold levels after further studies. As an apoptosis-related biomarker, serum M30 level has a merit to be the most promising test for prediction or differential diagnosis of HELLP syndrome in PE patients.en_US
dc.description.sponsorshipOur University Scientific Research and Projects Unit ["BAP": T-603]en_US
dc.description.sponsorshipThe study was funded by Our University Scientific Research and Projects Unit ("BAP": T-603).en_US
dc.language.isoengen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.isversionof10.1007/s00404-015-3803-1en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiopoietin-1en_US
dc.subjectAngiopoietin-2en_US
dc.subjectEndothelin-1en_US
dc.subjectM30en_US
dc.subjectHELLP syndromeen_US
dc.subjectPreeclampsiaen_US
dc.titleSerum levels of ET-1, M30, and angiopoietins-1 and-2 in HELLP syndrome and preeclampsia compared to controlsen_US
dc.typearticleen_US
dc.relation.journalARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.contributor.department[Karakus, Savas -- Akkar, Ozlem Bozoklu -- Yildiz, Caglar -- Cetin, Meral -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894en_US
dc.identifier.volume293en_US
dc.identifier.issue2en_US
dc.identifier.endpage359en_US
dc.identifier.startpage351en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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