dc.contributor.author | Sahin, A. | |
dc.contributor.author | Yetisgin, A. | |
dc.contributor.author | Sahin, M. | |
dc.contributor.author | Durmaz, Y. | |
dc.contributor.author | Cengiz, A. K. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:46:13Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:46:13Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0043-3144 | |
dc.identifier.uri | https://dx.doi.org/10.7727/wimj.2014.202 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7483 | |
dc.description | WOS: 000393480700027 | en_US |
dc.description | PubMed ID: 26645595 | en_US |
dc.description.abstract | Background: In humans, it has been suggested that low-level mean platelet volume (MPV) may be related to secondary thrombosis due to inflammation. For this reason, MPV can be used as a marker showing inflammation in the body. Objectives: To evaluate the association of MPV with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Disease Activity Score-28 (DAS-28), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with rheumatic diseases. Methods: The study consisted of 261 patients with rheumatoid arthritis (203 females, 77.8%; 58 males, 22.2%), 85 patients with ankylosing spondylitis (57 males, 67.1%; 28 females, 32.9%), 56 patients with familial Mediterranean fever (32 females, 57.1%; 24 males, 42.9%) and 194 patients (139 females, 71.6%; 55 males, 28.4%) with other rheumatic diseases (Behcet's disease, psoriatic arthritis, spondyloarthropathy, systemic lupus erythematosus, systemic sclerosis, or undifferentiated connective tissue disease). Results: There was an inversely significant correlation between MPV and ESR and CRP in patients with rheumatoid arthritis (r = -0.164, p = 0.008). Mean platelet volume was negatively correlated with DAS-28- ESR/CRP (r = -0.393, p < 0.001) in rheumatoid arthritis. Mean platelet volume was inversely correlated with BASDAI (r = -0.580, p < 0.001) in ankylosing spondylitis. In the group with familial Mediterranean fever (especially M694V homozygous), there was a negative correlation between MPV and ESR and CRP (p < 0.001). Mean platelet volume and CRP were negatively correlated in psoriatic arthritis (r = -0.599, p = 0.011). Mean platelet volume and ESR were inversely related in patients with systemic lupus erythematosus (r = -0.421, p = 0.045). There was a negative correlation between MPV and ESR (r = -0.219, p = 0.002), and between MPV and CRP (r = -0.208, p = 0.004) in other rheumatic diseases. Conclusions: The lower MPV level surrogates active and/or chronic inflammatory state in the body. Thus, MPV may be used as a negative acute-phase reactant in rheumatic diseases. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | UNIV WEST INDIES FACULTY MEDICAL SCIENCES | en_US |
dc.relation.isversionof | 10.7727/wimj.2014.202 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Inflammation | en_US |
dc.subject | mean platelet volume | en_US |
dc.subject | rheumatic diseases | en_US |
dc.title | Can Mean Platelet Volume Be a Surrogate Marker of Inflammation in Rheumatic Diseases? | en_US |
dc.type | article | en_US |
dc.relation.journal | WEST INDIAN MEDICAL JOURNAL | en_US |
dc.contributor.department | [Sahin, A. -- Durmaz, Y. -- Cengiz, A. K.] Cumhuriyet Univ, Sch Med, Dept Rheumatol, TR-58140 Sivas, Turkey -- [Yetisgin, A.] Sanliurfa Educ & Res Hosp, Div Phys Therapy & Med, Sanliurfa, Turkey -- [Sahin, M.] Sivas Numune Hosp, Phys Therapy & Med Unit, Sivas, Turkey | en_US |
dc.identifier.volume | 65 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 169 | en_US |
dc.identifier.startpage | 165 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |