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dc.contributor.authorKacan, Turgut
dc.contributor.authorYucel, Birsen
dc.contributor.authorBahar, Seher
dc.contributor.authorCelasun, Gurol
dc.contributor.authorSeker, Mehmet M.
dc.contributor.authorBabacan, Nalan
dc.contributor.authorBahceci, Aykut
dc.contributor.authorKacan, Selen B.
dc.contributor.authorKilickap, Saadettin
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:46:27Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:46:27Z
dc.date.issued2016
dc.identifier.issn1306-133X
dc.identifier.urihttps://dx.doi.org/10.4999/uhod.161266
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7524
dc.descriptionWOS: 000388276400002en_US
dc.description.abstractSystemic activation of coagulation and fibrinolysis is frequently observed in cancer patients without thrombosis. Recent studies have showed the association between D-Dimer (DD) and metastatic spread and prognosis of cancer. We aimed to investigate the prognostic value of DD in patients with non metestatic breast cancer (nMBC) and evaluated the DD levels and other variables for overall survival (OS) using univariate and multivariate analyses in 448 patients. The median follow-up time was 50 months (3-151 months). There was only significant relationship between DD and distant metastases (p=0.052). Performance status (PS) (p<0.001 and < 0.001), stage (p<0.001 and < 0.001), CEA (p<0.001 and < 0.001), CA 15-3 (p<0.001 and < 0.001) and DD (p<0.001 and 0.034) were determined as prognostic factors for OS in univariate analysis. In multivariate analysis, PS (ECOG 0 vs ECOG 1, p=0.022; ECOG 0 vs ECOG >= 2, (p<0.001), stage (stage I vs stage II, p=0.566; stage I vs stage III, p=0.033), the CA 15-3 (p=0.048) and DD levels (p=0.015) were determined as independent prognostic factors for OS. In conclusion, pretreatment high DD level is an important prognostic factor in patients with non metastatic breast cancer and high DD levels were associated with poor outcome.en_US
dc.language.isoengen_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.isversionof10.4999/uhod.161266en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectD-Dimeren_US
dc.subjectNon-metastatic breast canceren_US
dc.subjectPrognosisen_US
dc.titleThe Prognostic Value of High Pretreatment Plasma D-Dimer Levels in Non-Metastatic Breast Cancer Patients with Absence of Venous Thromboembolismen_US
dc.typearticleen_US
dc.relation.journalUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.contributor.department[Kacan, Turgut] Afyonkarahisar State Hosp, Div Med Oncol, Afyon, Turkey -- [Yucel, Birsen -- Bahar, Seher -- Celasun, Gurol] Cumhuriyet Univ, Fac Med, Div Radiat Oncol, Sivas, Turkey -- [Seker, Mehmet M.] Turgut Ozal Univ, Fac Med, Div Med Oncol, Ankara, Turkey -- [Babacan, Nalan] Marmara Univ, Pendik Training & Res Hosp, Div Med Oncol, Istanbul, Turkey -- [Bahceci, Aykut] Cumhuriyet Univ, Fac Med, Div Med Oncol, Sivas, Turkey -- [Kacan, Selen B.] Afyonkarahisar State Hosp, Div Internal Med, Afyon, Turkey -- [Kilickap, Saadettin] Hacettepe Univ, Fac Med, Div Med Oncol, Ankara, Turkeyen_US
dc.identifier.volume26en_US
dc.identifier.issue3en_US
dc.identifier.endpage144en_US
dc.identifier.startpage136en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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