dc.contributor.author | Polat, Fikriye | |
dc.contributor.author | Turaclar, Nesrin | |
dc.contributor.author | Yilmaz, Meral | |
dc.contributor.author | Bingol, Gunsel | |
dc.contributor.author | Cingilli Vural, Hasibe | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:46:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:46:49Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1300-0144 | |
dc.identifier.issn | 1303-6165 | |
dc.identifier.uri | https://dx.doi.org/10.3906/sag-1411-8 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7582 | |
dc.description | WOS: 000374327500013 | en_US |
dc.description | PubMed ID: 27513240 | en_US |
dc.description.abstract | Background/aim: The purpose of the present study was to investigate whether endothelial nitric oxide synthase (eNOS) gene polymorphisms play a role in prostate cancer (PCa). Materials and methods: We examined three eNOS gene polymorphisms (T-786C promoter region, G894T, and Intron 4 VNTR 4a/b) at extracted DNAs from 50 formalin-fixed paraffin-embedded tissues of PCa patients. For the controls, blood samples obtained from 50 healthy men were studied. Genotyping of molecular variants was performed by PCR-RFLP technique. Results: We found that the TC genotype of the T-786C polymorphism was associated with PCa risk (OR: 3.325, CI: 1.350-8.188, P = 0.008). The eNOS G894T polymorphism was also associated with PCa. The frequency of the 894T allele was significantly higher in PCa patients. No association was identified between intron 4 VNTR polymorphism and PCa. Conclusion: We found significant differences in genotypic and allelic frequencies between PCa patients and controls for eNOS T-786C and G894T polymorphisms. The presence of the T-786C genotype and 894T allele in carriers increased the risk of PCa. No association was found between intron 4 VNTR polymorphism and PCa patients. | en_US |
dc.description.sponsorship | Scientific Research Unit, Kocaeli University [2013/025] | en_US |
dc.description.sponsorship | We thank the Molecular Biology Research Laboratory of the Department of Biology at Kocaeli University for providing technical support. This investigation was supported by the Scientific Research Unit, Kocaeli University (2013/025). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY | en_US |
dc.relation.isversionof | 10.3906/sag-1411-8 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | prostate cancer | en_US |
dc.subject | eNOS | en_US |
dc.title | eNOS gene polymorphisms in paraffin-embedded tissues of prostate cancer patients | en_US |
dc.type | article | en_US |
dc.relation.journal | TURKISH JOURNAL OF MEDICAL SCIENCES | en_US |
dc.contributor.department | [Polat, Fikriye] Kocaeli Univ, Dept Primary Educ, Fac Educ, Elementary Sci Educ, Campus Umuttepe, Kocaeli, Turkey -- [Turaclar, Nesrin] Selcuk Univ, Vocat Sch Hlth Serv, Konya, Turkey -- [Yilmaz, Meral] Cumhuriyet Univ, Dept Res Ctr, Fac Med, Sivas, Turkey -- [Bingol, Gunsel] Yildirim Beyazit Univ, Fac Engn & Nat Sci, Biomed Engn, Ankara, Turkey -- [Cingilli Vural, Hasibe] Selcuk Univ, Mol Biol, Dept Biol, Konya, Turkey | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 679 | en_US |
dc.identifier.startpage | 673 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |