dc.contributor.author | Ulusoy, Songul | |
dc.contributor.author | Acidereli, Hilal | |
dc.contributor.author | Erdogan, Selim | |
dc.contributor.author | Ulusoy, Halil Ibrahim | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:46:51Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:46:51Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2046-2069 | |
dc.identifier.uri | https://dx.doi.org/10.1039/c6ra05286j | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7587 | |
dc.description | WOS: 000374974300070 | en_US |
dc.description.abstract | A fast, efficient, cost-effective, and environmental-friendly analytical methodology was developed for preconcentration and determination of trace folic acid in food samples prior to high performance liquid chromatography with diode array detection (HPLC-DAD). The method is based on formation of stable complexes between folic acid and Fe(III) ions at pH 8.0. The formed complexes were extracted to a nonionic surfactant phase containing PONPE 7.5. The surfactant rich phase (SRP) was separated by decantation and diluted with 300 mu L of a mixture of 1 M HCl and methanol at a 1 : 1 ratio. The parameters and variables that affected the method were also investigated and optimized in detail. The limit of detection (LOD) of folic acid was 6.06 ng mL(-1), the linear range of quantitation for folic acid was 20-1200 ng mL(-1) and the correlation coefficients of the calibration curves were 0.9976. The average recoveries and relative standard deviations in the analysis of real samples were in the range of 95.1-105.1% and 1.73-5.25%, respectively. After validation of the method was carried out, the method was applied to the determination of folic acid in real samples, including baby foods, vegetables, cereals, and pharmaceutical samples. | en_US |
dc.description.sponsorship | Cumhuriyet University Scientic Research Projects Commission [ECZ-004] | en_US |
dc.description.sponsorship | This study has been supported by Cumhuriyet University Scientific Research Projects Commission as the research project with the ECZ-004 code. Authors gratefully thank Prof. Dr Sahin YILDIRIM for his useful comments and contributions to the preparation of the project text. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ROYAL SOC CHEMISTRY | en_US |
dc.relation.isversionof | 10.1039/c6ra05286j | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | A new approach to the determination of folic acid at trace levels: using a Fe(III)-folic acid complex to amplify analytical signal | en_US |
dc.type | article | en_US |
dc.relation.journal | RSC ADVANCES | en_US |
dc.contributor.department | [Ulusoy, Songul] Cumhuriyet Univ, Fac Technol, Dept Biomed Engn, TR-58140 Sivas, Turkey -- [Acidereli, Hilal] Cumhuriyet Univ, Fac Pharm, Dept Biochem, TR-58140 Sivas, Turkey -- [Erdogan, Selim] Inonu Univ, Fac Pharm, Dept Analyt Chem, TR-44100 Malatya, Turkey -- [Ulusoy, Halil Ibrahim] Cumhuriyet Univ, Fac Pharm, Dept Analyt Chem, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Ulusoy, Halil Ibrahim -- 0000-0002-8742-5145 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 46 | en_US |
dc.identifier.endpage | 40122 | en_US |
dc.identifier.startpage | 40115 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |